Eml2 MGI Mouse Gene Detail - MGI:1919455 - echinoderm microtubule associated protein like 2

Symbol

Eml2
Name

echinoderm microtubule associated protein like 2
Synonyms

1600029N02Rik

Feature Type

protein coding gene
IDs

MGI:1919455
NCBI Gene: 72205
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr7:18910346-18940407 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

906 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919455	protein coding gene	Chr7:18910322-18940407 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031764	protein coding gene	Chr7:17139220-17173341 (+)
A/J	MGP_AJ_G0031740	protein coding gene	Chr7:16818002-16848352 (+)
AKR/J	MGP_AKRJ_G0031666	protein coding gene	Chr7:17274971-17304809 (+)
BALB/cJ	MGP_BALBcJ_G0031745	protein coding gene	Chr7:17010633-17050196 (+)
C3H/HeJ	MGP_C3HHeJ_G0031467	protein coding gene	Chr7:17540663-17574233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032211	protein coding gene	Chr7:18025183-18055092 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029277	protein coding gene	Chr7:18465214-18494772 (+)
CAST/EiJ	MGP_CASTEiJ_G0030810	protein coding gene	Chr7:13938230-13978092 (+)
CBA/J	MGP_CBAJ_G0031429	protein coding gene	Chr7:18680810-18722618 (+)
DBA/2J	MGP_DBA2J_G0031584	protein coding gene	Chr7:16752918-16785606 (+)
FVB/NJ	MGP_FVBNJ_G0031536	protein coding gene	Chr7:16617512-16649215 (+)
LP/J	MGP_LPJ_G0031667	protein coding gene	Chr7:17478877-17512393 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031572	protein coding gene	Chr7:18536621-18569659 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032239	protein coding gene	Chr7:16885739-16916005 (+)
PWK/PhJ	MGP_PWKPhJ_G0030534	protein coding gene	Chr7:13841964-13872708 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030361	protein coding gene	Chr7:11581678-11622929 (+)
WSB/EiJ	MGP_WSBEiJ_G0030910	protein coding gene	Chr7:17093472-17129177 (+)

Human Ortholog

EML2, EMAP like 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EML2, EMAP like 2
Synonyms

ELP70, EMAP-2, EMAP2
Links

HGNC:18035

NCBI Gene ID: 24139

neXtProt AC: NX_O95834

UniProt: O95834
Chr Location

19q13.32; chr19:45606994-45645629 (-) GRCh38

MGI Vertebrate Homology

Eml2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EML2
Gene Tree

Eml2

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

4
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

93 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

34
cDNA Data

31
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eml2

ZFIN eml2

less

All Sequences

67
RefSeq

17
UniProt

4
CCDS

CCDS52055.1, CCDS85223.1, CCDS85224.1

Ensembl

ENSMUSG00000040811 (Evidence)
NCBI Gene

72205

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040811	Ensembl Gene Model \| MGI Sequence Detail	30062	C57BL/6J	± kb
transcript	ENSMUST00000117338	Ensembl \| MGI Sequence Detail	2765	Not Applicable
polypeptide	ENSMUSP00000112491	Ensembl \| MGI Sequence Detail	841	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000007057 echinoderm microtubule-associated protein-like 2

(term hierarchy)
InterPro Domains

IPR005108 HELP motif

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR050630 WD repeat Echinoderm Microtubule-associated Protein-like
GlyGen

Q7TNG5 1 site, 1 O-linked glycan (1 site)

less

All nucleic 34

cDNA 31

Primer pair 3

Microarray probesets 3

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eml2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64790	Chr7:18910341-18910365 (+)	7 bp
Tssr64791	Chr7:18910371-18910399 (+)	39 bp
Tssr64792	Chr7:18910408-18910437 (+)	77 bp
Tssr64793	Chr7:18910438-18910462 (+)	104 bp
Tssr64794	Chr7:18910573-18910618 (+)	250 bp
Tssr64795	Chr7:18912128-18912164 (+)	1,800 bp
Tssr64796	Chr7:18912906-18912962 (+)	2,588 bp
Tssr64801	Chr7:18936297-18936309 (+)	25,957 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24