Tbc1d5 MGI Mouse Gene Detail - MGI:1919488 - TBC1 domain family, member 5

Symbol

Tbc1d5
Name

TBC1 domain family, member 5
Synonyms

1600014N05Rik

Feature Type

protein coding gene
IDs

MGI:1919488
NCBI Gene: 72238
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:51040152-51486380 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 26.47 cM
Mapping Data

1 experiment

SNPs within 2kb

10071 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919488	protein coding gene	Chr17:51040152-51488228 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023883	protein coding gene	Chr17:52167994-52646614 (-)
A/J	MGP_AJ_G0023843	protein coding gene	Chr17:50750744-51196866 (-)
AKR/J	MGP_AKRJ_G0023811	protein coding gene	Chr17:51313932-51786612 (-)
BALB/cJ	MGP_BALBcJ_G0023845	protein coding gene	Chr17:50660158-51111522 (-)
C3H/HeJ	MGP_C3HHeJ_G0023608	protein coding gene	Chr17:52012105-52479283 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024289	protein coding gene	Chr17:54253376-54725286 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021737	protein coding gene	Chr17:47468744-47931774 (-)
CAST/EiJ	MGP_CASTEiJ_G0023090	protein coding gene	Chr17:52252394-52770175 (-)
CBA/J	MGP_CBAJ_G0023584	protein coding gene	Chr17:56278436-56768070 (-)
DBA/2J	MGP_DBA2J_G0023713	protein coding gene	Chr17:49511795-49991042 (-)
FVB/NJ	MGP_FVBNJ_G0023679	protein coding gene	Chr17:49190587-49643176 (-)
LP/J	MGP_LPJ_G0023793	protein coding gene	Chr17:52872580-53347796 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023707	protein coding gene	Chr17:55630780-56224823 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024334	protein coding gene	Chr17:51622558-52091737 (-)
PWK/PhJ	MGP_PWKPhJ_G0022835	protein coding gene	Chr17:48960552-49420600 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022649	protein coding gene	Chr17:48577776-49056143 (-)
WSB/EiJ	MGP_WSBEiJ_G0023154	protein coding gene	Chr17:52248950-52718139 (-)

Human Ortholog

TBC1D5, TBC1 domain family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D5, TBC1 domain family member 5
Links

HGNC:19166

NCBI Gene ID: 9779

neXtProt AC: NX_Q92609

UniProt: Q92609
Chr Location

3p24.3; chr3:17157162-18444817 (-) GRCh38

MGI Vertebrate Homology

Tbc1d5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D5
Gene Tree

Tbc1d5

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

2
Gene trapped

11
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

51
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d5

ZFIN tbc1d5

less

All Sequences

63
RefSeq

14
UniProt

7
CCDS

CCDS37650.1, CCDS89117.1

Ensembl

ENSMUSG00000023923 (Evidence)
NCBI Gene

72238

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023923	Ensembl Gene Model \| MGI Sequence Detail	446229	C57BL/6J	± kb
transcript	ENSMUST00000224528	Ensembl \| MGI Sequence Detail	4764	Not Applicable
polypeptide	ENSMUSP00000153172	Ensembl \| MGI Sequence Detail	837	Not Applicable

less

UniProt

7 Sequences
Protein Ontology

PR:000016119 TBC1 domain family member 5

(term hierarchy)
InterPro Domains

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily
GlyGen

Q80XQ2 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

less

All nucleic 53

cDNA 53

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbc1d5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148606	Chr17:51486277-51486371 (-)	56 bp
Tssr148605	Chr17:51482542-51482545 (-)	3,836 bp
Tssr148604	Chr17:51478659-51478675 (-)	7,713 bp
Tssr148603	Chr17:51391288-51391292 (-)	95,090 bp
Tssr148602	Chr17:51300705-51300716 (-)	185,669 bp
Tssr148601	Chr17:51186842-51186881 (-)	299,518 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24