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Kcnk10 Gene Detail
Summary
  • Symbol
    Kcnk10
  • Name
    potassium channel, subfamily K, member 10
  • Synonyms
    1700024D23Rik, 3010005K24Rik, Trek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919508
    NCBI Gene: 72258
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98395691-98544472 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 49.86 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919508
 protein coding gene Chr12:98395691-98544569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020005
 protein coding gene Chr12:99812455-99957295 (-)
A/J MGP_AJ_G0019960
 protein coding gene Chr12:96079998-96211238 (-)
AKR/J MGP_AKRJ_G0019936
 protein coding gene Chr12:98679445-98817970 (-)
BALB/cJ MGP_BALBcJ_G0019946
 protein coding gene Chr12:96411406-96542740 (-)
C3H/HeJ MGP_C3HHeJ_G0019748
 protein coding gene Chr12:99225058-99356614 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020395
 protein coding gene Chr12:102872216-103018056 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018009
 protein coding gene Chr12:93048538-93182235 (-)
CAST/EiJ MGP_CASTEiJ_G0019294
 protein coding gene Chr12:94267770-94408936 (-)
CBA/J MGP_CBAJ_G0019720
 protein coding gene Chr12:106672574-106838567 (-)
DBA/2J MGP_DBA2J_G0019831
 protein coding gene Chr12:95493074-95634654 (-)
FVB/NJ MGP_FVBNJ_G0019820
 protein coding gene Chr12:94217988-94358225 (-)
LP/J MGP_LPJ_G0019907
 protein coding gene Chr12:99638355-99801136 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019862
 protein coding gene Chr12:110386424-110522463 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020424
 protein coding gene Chr12:98239830-98372514 (-)
PWK/PhJ MGP_PWKPhJ_G0019058
 protein coding gene Chr12:90106050-90248381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018854
 protein coding gene Chr12:92403397-92540796 (-)
WSB/EiJ MGP_WSBEiJ_G0019348
 protein coding gene Chr12:99058305-99207442 (-)



Homology
more
  • Human Ortholog
    KCNK10, potassium two pore domain channel subfamily K member 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK10, potassium two pore domain channel subfamily K member 10
  • Synonyms
    K2p10.1, PPP1R97, TREK-2, TREK2
  • Links
    NCBI Gene ID: 54207
    neXtProt AC: NX_P57789
    UniProt: P57789

  • Chr Location
    14q31.3; chr14:88180103-88326912 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    13 phenotype references
Mice homozygous for a null allele exhibit normal glucose hyperpolarization of hypothalamic neurons in response to glucose.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    23
  • cDNA Data
    13
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72258 NCBI Gene Model | MGI Sequence Detail 148782 C57BL/6J ±  kb
transcript NM_001316665 RefSeq | MGI Sequence Detail 7491 C57BL/6  
polypeptide Q8BUW1 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR003280 Two pore domain potassium channel
    IPR003976 Two pore domain potassium channel, TREK
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1924704
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:324668 Glogowska E, et al., Piezo1 and Piezo2 foster mechanical gating of K2P channels. Cell Rep. 2021 Nov 30;37(9):110070
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory