Cda MGI Mouse Gene Detail - MGI:1919519

Symbol

Cda
Name

cytidine deaminase
Synonyms

2210401N16Rik

Feature Type

protein coding gene
IDs

MGI:1919519
NCBI Gene: 72269
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:138065735-138095303 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.17 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

976 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919519	protein coding gene	Chr4:138065735-138095623 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028995	protein coding gene	Chr4:141069039-141102005 (-)
A/J	MGP_AJ_G0028954	protein coding gene	Chr4:135038998-135071185 (-)
AKR/J	MGP_AKRJ_G0028906	protein coding gene	Chr4:138887860-138919059 (-)
BALB/cJ	MGP_BALBcJ_G0028978	protein coding gene	Chr4:135711142-135741867 (-)
C3H/HeJ	MGP_C3HHeJ_G0028692	protein coding gene	Chr4:139253707-139284890 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029419	protein coding gene	Chr4:146083638-146115047 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026690	protein coding gene	Chr4:128019513-128049257 (-)
CAST/EiJ	MGP_CASTEiJ_G0028124	protein coding gene	Chr4:137412964-137445227 (-)
CBA/J	MGP_CBAJ_G0028657	protein coding gene	Chr4:150239734-150280950 (-)
DBA/2J	MGP_DBA2J_G0028806	protein coding gene	Chr4:135417290-135448669 (-)
FVB/NJ	MGP_FVBNJ_G0028773	protein coding gene	Chr4:134436781-134468266 (-)
LP/J	MGP_LPJ_G0028905	protein coding gene	Chr4:141149670-141180051 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028799	protein coding gene	Chr4:154255647-154290793 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029457	protein coding gene	Chr4:139401669-139443782 (-)
PWK/PhJ	MGP_PWKPhJ_G0027845	protein coding gene	Chr4:132266579-132299892 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027670	protein coding gene	Chr4:135180386-135210718 (-)
WSB/EiJ	MGP_WSBEiJ_G0028202	protein coding gene	Chr4:139634428-139668863 (-)

Human Ortholog

CDA, cytidine deaminase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDA, cytidine deaminase
Synonyms

CDD
Links

HGNC:1712

NCBI Gene ID: 978

neXtProt AC: NX_P32320

UniProt: P32320
Chr Location

1p36.12; chr1:20589086-20618903 (+) GRCh38

MGI Vertebrate Homology

Cda stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CDA
Gene Tree

Cda

Diseases

1 with human CDA associations

				Human Disease	Mouse Models
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

3
Targeted

6
Genomic Mutations

3 involving Cda
Incidental Mutations

CvDC
Find Mice (IMSR)

8 strains or lines available

Mice homozygous for a knock-out allele appear healthy and exhibit a normal lifespan with no detectable behavioral phenotypes or changes in the frequency or type of spontaneous tumors. Despite a mild genetic instability in primary kidney cells, homozygotes show decreased incidence of chemically induced colon tumors.

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All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

901
Tissues

96
cDNA Data

25
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cda

ZFIN cdab

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS18826.1

Ensembl

ENSMUSG00000028755 (Evidence)
NCBI Gene

72269

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028755	Ensembl Gene Model \| MGI Sequence Detail	29569	C57BL/6J	± kb
transcript	ENSMUST00000030535	Ensembl \| MGI Sequence Detail	846	Not Applicable
polypeptide	ENSMUSP00000030535	Ensembl \| MGI Sequence Detail	146	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005180 cytidine deaminase

(term hierarchy)
PDB

1ZAB, 2FR5, 2FR6
EC

3.5.4.5
InterPro Domains

IPR016192 APOBEC/CMP deaminase, zinc-binding

IPR050202 Cytidine and Deoxycytidylate Deaminase

IPR002125 Cytidine and deoxycytidylate deaminase domain

IPR006262 Cytidine deaminase, homotetrameric

IPR016193 Cytidine deaminase-like

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 3

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 10
Earliest

J:307215 Tomchick R, et al., Mouse kidney cytidine deaminase. Purification and properties. J Biol Chem. 1968 May 25;243(10):2534-7
Latest

J:332259 Onclercq-Delic R, et al., Cytidine deaminase deficiency in mice enhances genetic instability but limits the number of chemically induced colon tumors. Cancer Lett. 2022 Dec 8;555:216030

TSS for Cda:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44163	Chr4:138095277-138095319 (-)	5 bp
Tssr44162	Chr4:138095263-138095276 (-)	33 bp
Tssr44161	Chr4:138095192-138095203 (-)	105 bp
Tssr44160	Chr4:138070926-138070952 (-)	24,364 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24