Rusc1 MGI Mouse Gene Detail - MGI:1919546 - RUN and SH3 domain containing 1

Symbol

Rusc1
Name

RUN and SH3 domain containing 1
Synonyms

2210403N08Rik

Feature Type

protein coding gene
IDs

MGI:1919546
NCBI Gene: 72296
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:88991288-89000618 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.01 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919546	protein coding gene	Chr3:88991282-89000670 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027414	protein coding gene	Chr3:89268369-89277699 (-)
A/J	MGP_AJ_G0027378	protein coding gene	Chr3:86323616-86332958 (-)
AKR/J	MGP_AKRJ_G0027342	protein coding gene	Chr3:88409155-88418497 (-)
BALB/cJ	MGP_BALBcJ_G0027387	protein coding gene	Chr3:86292646-86301976 (-)
C3H/HeJ	MGP_C3HHeJ_G0027129	protein coding gene	Chr3:88610244-88619586 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027833	protein coding gene	Chr3:92634949-92644279 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025185	protein coding gene	Chr3:81809899-81819423 (-)
CAST/EiJ	MGP_CASTEiJ_G0026575	protein coding gene	Chr3:88954293-88963615 (-)
CBA/J	MGP_CBAJ_G0027103	protein coding gene	Chr3:95825581-95834927 (-)
DBA/2J	MGP_DBA2J_G0027241	protein coding gene	Chr3:85708340-85717670 (-)
FVB/NJ	MGP_FVBNJ_G0027209	protein coding gene	Chr3:84036758-84046096 (-)
LP/J	MGP_LPJ_G0027350	protein coding gene	Chr3:90351682-90361012 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027229	protein coding gene	Chr3:102046374-102055704 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027892	protein coding gene	Chr3:88161004-88170346 (-)
PWK/PhJ	MGP_PWKPhJ_G0026309	protein coding gene	Chr3:85570072-85579514 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026128	protein coding gene	Chr3:87327979-87337300 (-)
WSB/EiJ	MGP_WSBEiJ_G0026657	protein coding gene	Chr3:88549847-88559177 (-)

Human Ortholog

RUSC1, RUN and SH3 domain containing 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RUSC1, RUN and SH3 domain containing 1
Synonyms

NESCA
Links

HGNC:17153

NCBI Gene ID: 23623

neXtProt AC: NX_Q9BVN2

UniProt: Q9BVN2
Chr Location

1q22; chr1:155320894-155331118 (+) GRCh38

MGI Vertebrate Homology

Rusc1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: RUSC1
Gene Tree

Rusc1

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Rusc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

846
Tissues

19
cDNA Data

60
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rusc1

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All Sequences

68
RefSeq

8
UniProt

5
CCDS

CCDS38485.1, CCDS38486.1, CCDS50956.1

Ensembl

ENSMUSG00000041263 (Evidence)
NCBI Gene

72296

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041263	Ensembl Gene Model \| MGI Sequence Detail	9331	C57BL/6J	± kb
transcript	ENSMUST00000090929	Ensembl \| MGI Sequence Detail	3706	Not Applicable
polypeptide	ENSMUSP00000088447	Ensembl \| MGI Sequence Detail	1030	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014366 AP-4 complex accessory subunit RUSC1

(term hierarchy)
InterPro Domains

IPR047343 AP-4 complex accessory subunit RUSC1/2

IPR047341 AP-4 complex accessory subunit RUSC1, RUN domain

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q8BG26 1 site, 1 N-linked glycan (1 site)

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All nucleic 60

cDNA 60

Microarray probesets 7

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MGI:2139558

Summaries

All 41

Developmental Gene Expression 4

Diseases 1

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rusc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34089	Chr3:89002163-89002167 (-)	-1,547 bp
Tssr34088	Chr3:89000676-89000679 (-)	-60 bp
Tssr34087	Chr3:89000665-89000674 (-)	-52 bp
Tssr34086	Chr3:89000592-89000663 (-)	-10 bp
Tssr34085	Chr3:88998837-88998877 (-)	1,761 bp
Tssr34084	Chr3:88997262-88997315 (-)	3,329 bp
Tssr34083	Chr3:88997161-88997177 (-)	3,449 bp
Tssr34082	Chr3:88997055-88997066 (-)	3,557 bp
Tssr34081	Chr3:88997006-88997023 (-)	3,603 bp
Tssr34080	Chr3:88996967-88996976 (-)	3,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24