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Brf1 Gene Detail
Summary
  • Symbol
    Brf1
  • Name
    BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
  • Synonyms
    2510002F24Rik, GTF3B, TAF3C, TAFIII90, TFIIIB90
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919558
    NCBI Gene: 72308
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112923705-112964324 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.47 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    951 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919558
 protein coding gene Chr12:112919251-112964327 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020166
 protein coding gene Chr12:115442758-115484097 (-)
A/J MGP_AJ_G0020122
 protein coding gene Chr12:110976738-111018760 (-)
AKR/J MGP_AKRJ_G0020097
 protein coding gene Chr12:114203011-114243994 (-)
BALB/cJ MGP_BALBcJ_G0020107
 protein coding gene Chr12:111441648-111483443 (-)
C3H/HeJ MGP_C3HHeJ_G0019909
 protein coding gene Chr12:114713811-114756916 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020552
 protein coding gene Chr12:118995003-119035724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018166
 protein coding gene Chr12:107413906-107454844 (-)
CAST/EiJ MGP_CASTEiJ_G0019449
 protein coding gene Chr12:109556657-109602647 (-)
CBA/J MGP_CBAJ_G0019876
 protein coding gene Chr12:123548193-123592928 (-)
DBA/2J MGP_DBA2J_G0019993
 protein coding gene Chr12:110478052-110518536 (-)
FVB/NJ MGP_FVBNJ_G0019978
 protein coding gene Chr12:109304684-109350603 (-)
LP/J MGP_LPJ_G0020067
 protein coding gene Chr12:115266103-115309915 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020016
 protein coding gene Chr12:126647315-126687825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020581
 protein coding gene Chr12:113712297-113758613 (-)
PWK/PhJ MGP_PWKPhJ_G0019211
 protein coding gene Chr12:105133783-105175153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019015
 protein coding gene Chr12:107892689-107933456 (-)
WSB/EiJ MGP_WSBEiJ_G0019509
 protein coding gene Chr12:114627484-114670338 (-)



Homology
more
  • Human Ortholog
    BRF1, BRF1 general transcription factor IIIB subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRF1, BRF1 general transcription factor IIIB subunit
  • Synonyms
    BRF, BRF-1, CFDS, GTF3B, hBRF, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90
  • Links
    NCBI Gene ID: 2972
    neXtProt AC: NX_Q92994
    UniProt: Q92994

  • Chr Location
    14q32.33; chr14:105209286-105315589 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BRF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality with failure of blastocyst. Mice homozygous for a conditional activated in different tissues exhibit reduced tRNA levels leading to apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000011158 Ensembl Gene Model | MGI Sequence Detail 40620 C57BL/6J ±  kb
    transcript ENSMUST00000011302 Ensembl | MGI Sequence Detail 2615 Not Applicable  
    polypeptide ENSMUSP00000011302 Ensembl | MGI Sequence Detail 676 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:285667 Liko D, et al., Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death Differ. 2019 Dec;26(12):2535-2550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory