Fam72a Gene Detail

Summary

• Symbol
  Fam72a
• Name
  family with sequence similarity 72, member A
• Synonyms
  2700049P18Rik, P17

• Feature Type
  protein coding gene
• IDs
  MGI:1919669
  NCBI Gene: 108900
• Alliance
  gene page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr1:131455641-131467610 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 56.99 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  293 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919669	protein coding gene	Chr1:131454336-131467610 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016454	protein coding gene	Chr1:134959121-134971092 (+)
A/J	MGP_AJ_G0016437	protein coding gene	Chr1:129969836-129981805 (+)
AKR/J	MGP_AKRJ_G0016402	protein coding gene	Chr1:133782598-133794567 (+)
BALB/cJ	MGP_BALBcJ_G0016397	protein coding gene	Chr1:130297044-130309015 (+)
C3H/HeJ	MGP_C3HHeJ_G0016223	protein coding gene	Chr1:133925812-133937782 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016858	protein coding gene	Chr1:139981463-139993432 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014572	protein coding gene	Chr1:123109484-123121634 (+)
CAST/EiJ	MGP_CASTEiJ_G0015803	protein coding gene	Chr1:132923494-132935513 (+)
CBA/J	MGP_CBAJ_G0016195	protein coding gene	Chr1:144772472-144784441 (+)
DBA/2J	MGP_DBA2J_G0016302	protein coding gene	Chr1:128935872-128947843 (+)
FVB/NJ	MGP_FVBNJ_G0016301	protein coding gene	Chr1:127565374-127577345 (+)
LP/J	MGP_LPJ_G0016373	protein coding gene	Chr1:136271687-136283658 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016326	protein coding gene	Chr1:150540288-150552257 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016894	protein coding gene	Chr1:133548602-133560573 (+)
PWK/PhJ	MGP_PWKPhJ_G0015589	protein coding gene	Chr1:127894253-127906564 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015376	protein coding gene	Chr1:132486266-132502430 (+)
WSB/EiJ	MGP_WSBEiJ_G0015865	protein coding gene	Chr1:133533584-133545574 (+)

Homology

• Human Ortholog
  FAM72A, family with sequence similarity 72 member A

• Vertebrate Orthologs
  6

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FAM72A, family with sequence similarity 72 member A
  
• Synonyms
  LMPIP, p17, Ugene
• Links
  HGNC:24044

  NCBI Gene ID: 729533

  neXtProt AC: NX_Q5TYM5

  UniProt: Q5TYM5

  
  
• Chr Location
  1q32.1; chr1:206186179-206205773 (-)  GRCh38

---

• Human Ortholog
  FAM72B, family with sequence similarity 72 member B
  
• Synonyms
  p17
• Links
  HGNC:24805

  NCBI Gene ID: 653820

  neXtProt AC: NX_Q86X60

  UniProt: Q86X60

  
  
• Chr Location
  1p11.2

---

• Human Ortholog
  FAM72C, family with sequence similarity 72 member C
  
• Links
  HGNC:30602

  NCBI Gene ID: 554282

  neXtProt AC: NX_H0Y354

  UniProt: H0Y354

  
  
• Chr Location
  chr1:143955287-143973564 (-)  GRCh38

---

• Human Ortholog
  FAM72D, family with sequence similarity 72 member D
  
• Synonyms
  GCUD2
• Links
  HGNC:33593

  NCBI Gene ID: 728833

  neXtProt AC: NX_Q6L9T8

  UniProt: Q6L9T8

  
  
• Chr Location
  1q21.1; chr1:145094296-145112696 (+)  GRCh38

---

• MGI Vertebrate Homology
  Fam72a stringent orthology
  4 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FAM72A, FAM72B, FAM72C, FAM72D
• Gene Tree
  Fam72a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 2 genetic backgrounds
  2 phenotypes from multigenic genotypes
  17 phenotype references
  

• All Mutations and Alleles
  17
• Chemically induced (other)
  2
• Endonuclease-mediated
  3
• Gene trapped
  7
• Radiation induced
  1
• Targeted
  4
• Genomic Mutations
  3 involving Fam72a
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  30 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired class switch recombination and somatic hypermutation with increased germinal center B cell numbers.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  4

Expression

• Assay Results
  725
• Tissues
  11
• cDNA Data
  11
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fam72a

Sequences &
Gene Models

• All Sequences
  38
• RefSeq
  4
• UniProt
  1
• CCDS
  CCDS15270.1

• Ensembl
  ENSMUSG00000055184 (Evidence)
• NCBI Gene
  108900

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000055184	Ensembl Gene Model | MGI Sequence Detail	11970	C57BL/6J
transcript	ENSMUST00000068613	Ensembl | MGI Sequence Detail	2191	Not Applicable
polypeptide	ENSMUSP00000068111	Ensembl | MGI Sequence Detail	149	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000030429 protein FAM72A
  (term hierarchy)
• InterPro Domains
  IPR026768 Yippee homolog double zinc finger protein

Molecular
Reagents

• All nucleic 11

  cDNA 11

  
  

  Microarray probesets 3

References

• Summaries
  All 40

  Developmental Gene Expression 1

  Gene Ontology 4

  Phenotypes 17
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fam72a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8629	Chr1:131455596-131455609 (+)	-38 bp
Tssr8630	Chr1:131455639-131455649 (+)	3 bp
Tssr8631	Chr1:131455718-131455740 (+)	88 bp
Tssr8632	Chr1:131456099-131456114 (+)	466 bp