Rbm33 MGI Mouse Gene Detail - MGI:1919670 - RNA binding motif protein 33

Symbol

Rbm33
Name

RNA binding motif protein 33
Synonyms

3200001K10Rik, 6430512A10Rik, Prr8

Feature Type

protein coding gene
IDs

MGI:1919670
NCBI Gene: 381626
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:28522119-28624237 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 14.36 cM, cytoband A3
Mapping Data

4 experiments

SNPs within 2kb

1876 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919670	protein coding gene	Chr5:28521817-28624242 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029371	protein coding gene	Chr5:26227048-26332602 (+)
A/J	MGP_AJ_G0029337	protein coding gene	Chr5:25340733-25444004 (+)
AKR/J	MGP_AKRJ_G0029288	protein coding gene	Chr5:26374615-26479457 (+)
BALB/cJ	MGP_BALBcJ_G0029348	protein coding gene	Chr5:25893815-25995574 (+)
C3H/HeJ	MGP_C3HHeJ_G0029069	protein coding gene	Chr5:26420496-26523767 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029801	protein coding gene	Chr5:27837502-27959652 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027039	protein coding gene	Chr5:22952065-23054146 (+)
CAST/EiJ	MGP_CASTEiJ_G0028480	protein coding gene	Chr5:25524953-25632258 (+)
CBA/J	MGP_CBAJ_G0029037	protein coding gene	Chr5:28338497-28451998 (+)
DBA/2J	MGP_DBA2J_G0029186	protein coding gene	Chr5:25563205-25666175 (+)
FVB/NJ	MGP_FVBNJ_G0029144	protein coding gene	Chr5:25003642-25105117 (+)
LP/J	MGP_LPJ_G0029271	protein coding gene	Chr5:26684738-26789921 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029173	protein coding gene	Chr5:29377507-29483110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029835	protein coding gene	Chr5:26010866-26111818 (+)
PWK/PhJ	MGP_PWKPhJ_G0028204	protein coding gene	Chr5:24686987-24790094 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028035	protein coding gene	Chr5:25284606-25391514 (+)
WSB/EiJ	MGP_WSBEiJ_G0028560	protein coding gene	Chr5:26003487-26107744 (+)

Human Ortholog

RBM33, RNA binding motif protein 33

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM33, RNA binding motif protein 33
Synonyms

PRR8
Links

HGNC:27223

NCBI Gene ID: 155435

neXtProt AC: NX_Q96EV2

UniProt: Q96EV2
Chr Location

7q36.3; chr7:155644451-155781485 (+) GRCh38

MGI Vertebrate Homology

Rbm33 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBM33
Gene Tree

Rbm33

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References

2 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

62
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

51
Radiation induced

4
Spontaneous

1
Targeted

2
Genomic Mutations

7 involving Rbm33
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

60 strains or lines available

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

118
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm33

ZFIN rbm33a

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All Sequences

61
RefSeq

8
UniProt

6
CCDS

CCDS51448.1

Ensembl

ENSMUSG00000048271 (Evidence)
NCBI Gene

381626

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048271	Ensembl Gene Model \| MGI Sequence Detail	102119	C57BL/6J	± kb
transcript	ENSMUST00000059644	Ensembl \| MGI Sequence Detail	9510	Not Applicable
polypeptide	ENSMUSP00000062449	Ensembl \| MGI Sequence Detail	1231	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013794 RNA-binding protein 33

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR039878 RNA-binding protein 33

IPR000504 RNA recognition motif domain
GlyGen

Q9CXK9 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 119

cDNA 118

Primer pair 1

Microarray probesets 7

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MGI:3026957, MGI:3035054

Summaries

All 70

Developmental Gene Expression 2

Diseases 2

Gene Ontology 5

Phenotypes 39
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbm33:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45517	Chr5:28521842-28521918 (+)	-239 bp
Tssr45518	Chr5:28521926-28522006 (+)	-153 bp
Tssr45519	Chr5:28522151-28522218 (+)	66 bp
Tssr45520	Chr5:28522884-28522888 (+)	767 bp
Tssr45522	Chr5:28559846-28559851 (+)	37,730 bp
Tssr45523	Chr5:28573238-28573282 (+)	51,141 bp
Tssr45524	Chr5:28578086-28578090 (+)	55,969 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24