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Tagap1 Gene Detail
Summary
  • Symbol
    Tagap1
  • Name
    T cell activation GTPase activating protein 1
  • Synonyms
    2610315E15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919786
    NCBI Gene: 380608
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr17:7222410-7228555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 4.55 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919786
 protein coding gene Chr17:7222364-7246122 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023124
 protein coding gene Chr17:5235467-5238299 (+)
A/J MGP_AJ_G0023096
 protein coding gene Chr17:5437912-5440721 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0023089
 protein coding gene Chr17:4236748-4243451 (-)
C3H/HeJ MGP_C3HHeJ_G0022857
 protein coding gene Chr17:5335101-5337929 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023537
 protein coding gene Chr17:5453257-5456068 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021039
 protein coding gene Chr17:3933751-3941819 (-)
CAST/EiJ MGP_CASTEiJ_G0022368
 protein coding gene Chr17:5146250-5149056 (+)
CBA/J MGP_CBAJ_G0022827
 protein coding gene Chr17:5802437-5805264 (+)
DBA/2J MGP_DBA2J_G0022955
 protein coding gene Chr17:4136741-4142948 (-)
FVB/NJ MGP_FVBNJ_G0022933
 protein coding gene Chr17:5018453-5021281 (+)
LP/J MGP_LPJ_G0023023
 protein coding gene Chr17:4289265-4292068 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022952
 protein coding gene Chr17:5578632-5581460 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023563
 protein coding gene Chr17:5358719-5361527 (+)
PWK/PhJ MGP_PWKPhJ_G0022117
 protein coding gene Chr17:4681625-4689676 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021940
 protein coding gene Chr17:3922320-3925128 (-)
WSB/EiJ MGP_WSBEiJ_G0022424
 protein coding gene Chr17:5395520-5399246 (+)



Homology
more
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAGAP, T cell activation RhoGTPase activating protein
  • Synonyms
    ARHGAP47, FKSG15, IDDM21, TAGAP1
  • Links
    NCBI Gene ID: 117289
    neXtProt AC: NX_Q8N103
    UniProt: Q8N103

  • Chr Location
    6q25.3; chr6:159034468-159095823 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    357 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052031 Ensembl Gene Model | MGI Sequence Detail 6146 C57BL/6J ±  kb
    transcript ENSMUST00000063683 Ensembl | MGI Sequence Detail 2312 Not Applicable  
    polypeptide ENSMUSP00000070466 Ensembl | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146765
    References
    more
    • Summaries
      All 374
      Diseases 6
      Phenotypes 357
    • Earliest
      J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
    • Latest
      J:354984 Emili M, et al., Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model. Neuropharmacology. 2024 Sep 27;261:110170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory