Shisa9 MGI Mouse Gene Detail - MGI:1919805

Symbol

Shisa9
Name

shisa family member 9
Synonyms

2700045P11Rik, CKAMP44

Feature Type

protein coding gene
IDs

MGI:1919805
NCBI Gene: 72555
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:11801977-12088766 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 6.89 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

7546 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919805	protein coding gene	Chr16:11801457-12088768 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022528	protein coding gene	Chr16:8890800-9196984 (+)
A/J	MGP_AJ_G0022490	protein coding gene	Chr16:8394657-8687173 (+)
AKR/J	MGP_AKRJ_G0022466	protein coding gene	Chr16:8777542-9075924 (+)
BALB/cJ	MGP_BALBcJ_G0022494	protein coding gene	Chr16:8542488-8833377 (+)
C3H/HeJ	MGP_C3HHeJ_G0022261	protein coding gene	Chr16:8844679-9140329 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022943	protein coding gene	Chr16:9036749-9365380 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020463	protein coding gene	Chr16:8557307-8849923 (+)
CAST/EiJ	MGP_CASTEiJ_G0021788	protein coding gene	Chr16:8875700-9186713 (+)
CBA/J	MGP_CBAJ_G0022230	protein coding gene	Chr16:9446538-9756737 (+)
DBA/2J	MGP_DBA2J_G0022361	protein coding gene	Chr16:8406588-8695674 (+)
FVB/NJ	MGP_FVBNJ_G0022337	protein coding gene	Chr16:8400395-8689777 (+)
LP/J	MGP_LPJ_G0022429	protein coding gene	Chr16:8832347-9141249 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022359	protein coding gene	Chr16:9110487-9430520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022956	protein coding gene	Chr16:8726325-9024318 (+)
PWK/PhJ	MGP_PWKPhJ_G0021528	protein coding gene	Chr16:8635896-8928036 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021358	protein coding gene	Chr16:8787130-9082050 (+)
WSB/EiJ	MGP_WSBEiJ_G0021836	protein coding gene	Chr16:8810097-9101741 (+)

Human Ortholog

SHISA9, shisa family member 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHISA9, shisa family member 9
Synonyms

CKAMP44
Links

HGNC:37231

NCBI Gene ID: 729993

neXtProt AC: NX_B4DS77

UniProt: B4DS77
Chr Location

16p13.12; chr16:12901598-13563017 (+) GRCh38

MGI Vertebrate Homology

Shisa9 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: SHISA9
Gene Tree

Shisa9

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced AMPA-mediated synaptic currents in retinogeniculate and corticogeniculate synapses, enhanced paired-pulse facilitation in retinogeniculate synapses and decreased synaptic depression.

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All GO Annotations

28
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

744
Tissues

24
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase shisa9

ZFIN shisa9a

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All Sequences

53
RefSeq

15
UniProt

2
CCDS

CCDS49766.1, CCDS49767.1

Ensembl

ENSMUSG00000022494 (Evidence)
NCBI Gene

72555

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022494	Ensembl Gene Model \| MGI Sequence Detail	286790	C57BL/6J	± kb
transcript	ENSMUST00000170672	Ensembl \| MGI Sequence Detail	3421	Not Applicable
polypeptide	ENSMUSP00000132646	Ensembl \| MGI Sequence Detail	424	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031377 protein shisa-9

(term hierarchy)
InterPro Domains

IPR026910 Shisa family
GlyGen

Q9CZN4 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Shisa9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr137112	Chr16:11801971-11802017 (+)	17 bp
Tssr137113	Chr16:11802020-11802034 (+)	50 bp
Tssr137114	Chr16:11802225-11802246 (+)	259 bp
Tssr137115	Chr16:11802253-11802286 (+)	293 bp
Tssr137116	Chr16:12079128-12079130 (+)	277,152 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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