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Cul4b Gene Detail
Summary
  • Symbol
    Cul4b
  • Name
    cullin 4B
  • Synonyms
    2700050M05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919834
    NCBI Gene: 72584
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:37622151-37665073 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 22.81 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    742 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919834
 protein coding gene ChrX:37620493-37665073 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035666
 protein coding gene ChrX:33499278-33545335 (-)
A/J MGP_AJ_G0035651
 protein coding gene ChrX:33555221-33598127 (-)
AKR/J MGP_AKRJ_G0035568
 protein coding gene ChrX:34335685-34391106 (-)
BALB/cJ MGP_BALBcJ_G0035635
 protein coding gene ChrX:33259330-33303111 (-)
C3H/HeJ MGP_C3HHeJ_G0035339
 protein coding gene ChrX:33866591-33910976 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036166
 protein coding gene ChrX:34252749-34315020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033018
 protein coding gene ChrX:31966801-32010090 (-)
CAST/EiJ MGP_CASTEiJ_G0034630
 protein coding gene ChrX:21865737-21920844 (-)
CBA/J MGP_CBAJ_G0035313
 protein coding gene ChrX:35136964-35184255 (-)
DBA/2J MGP_DBA2J_G0035467
 protein coding gene ChrX:33388534-33436907 (-)
FVB/NJ MGP_FVBNJ_G0035416
 protein coding gene ChrX:33143345-33185312 (-)
LP/J MGP_LPJ_G0035555
 protein coding gene ChrX:33900604-33947132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035454
 protein coding gene ChrX:35461961-35528704 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036182
 protein coding gene ChrX:33546770-33589678 (-)
PWK/PhJ MGP_PWKPhJ_G0034331
 protein coding gene ChrX:21445328-21487237 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034176
 protein coding gene ChrX:22396426-22448284 (-)
WSB/EiJ MGP_WSBEiJ_G0034776
 protein coding gene ChrX:33229715-33273115 (-)



Homology
more
  • Human Ortholog
    CUL4B, cullin 4B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUL4B, cullin 4B
  • Synonyms
    CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
  • Links
    NCBI Gene ID: 8450
    neXtProt AC: NX_Q13620
    UniProt: Q13620

  • Chr Location
    Xq24; chrX:120505920-120604074 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cul4b mouse models; 1 with human CUL4B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 7 genetic backgrounds
    8 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the brain exhibit impaired spatial learning and memory, increased susceptibility to PTZ-induced seizures, abnormal dendrite morphology on hippocampal neurons. Mice homozygous for a null allele exhibitembryonic lethality and abnormal placenta.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    6
  • cDNA Data
    13
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031095 Ensembl Gene Model | MGI Sequence Detail 42923 C57BL/6J ±  kb
    transcript ENSMUST00000115118 Ensembl | MGI Sequence Detail 3344 Not Applicable  
    polypeptide ENSMUSP00000110771 Ensembl | MGI Sequence Detail 970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:3034471
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 16
      Phenotypes 35
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:352616 Guo B, et al., Enhanced Apc(Min/+) adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells. Neoplasia. 2024 Jul;53:101005
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory