About   Help   FAQ
Lypd1 Gene Detail
Summary
  • Symbol
    Lypd1
  • Name
    Ly6/Plaur domain containing 1
  • Synonyms
    2700050C12Rik, C530008O16Rik, Lynx2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919835
    NCBI Gene: 72585
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:125795359-125840838 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 54.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1491 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919835
 protein coding gene Chr1:125795359-125841134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016417
 protein coding gene Chr1:128980287-129027326 (-)
A/J MGP_AJ_G0016400
 protein coding gene Chr1:124233205-124279311 (-)
AKR/J MGP_AKRJ_G0016365
 protein coding gene Chr1:127862016-127911205 (-)
BALB/cJ MGP_BALBcJ_G0016360
 protein coding gene Chr1:124590063-124635888 (-)
C3H/HeJ MGP_C3HHeJ_G0016186
 protein coding gene Chr1:128066588-128112747 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016821
 protein coding gene Chr1:133852130-133897568 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014534
 protein coding gene Chr1:117635801-117680833 (-)
CAST/EiJ MGP_CASTEiJ_G0015767
 protein coding gene Chr1:126988265-127036143 (-)
CBA/J MGP_CBAJ_G0016159
 protein coding gene Chr1:138344175-138390719 (-)
DBA/2J MGP_DBA2J_G0016265
 protein coding gene Chr1:123237123-123283216 (-)
FVB/NJ MGP_FVBNJ_G0016264
 protein coding gene Chr1:121978476-122024448 (-)
LP/J MGP_LPJ_G0016336
 protein coding gene Chr1:130322792-130375279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016289
 protein coding gene Chr1:144308219-144353826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016857
 protein coding gene Chr1:127638623-127684229 (-)
PWK/PhJ MGP_PWKPhJ_G0015553
 protein coding gene Chr1:122215402-122261133 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015341
 protein coding gene Chr1:126582420-126630327 (-)
WSB/EiJ MGP_WSBEiJ_G0015829
 protein coding gene Chr1:127590956-127636331 (-)



Homology
more
  • Human Ortholog
    LYPD1, LY6/PLAUR domain containing 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPD1, LY6/PLAUR domain containing 1
  • Synonyms
    LYPDC1, PHTS
  • Links
    NCBI Gene ID: 116372
    neXtProt AC: NX_Q8N2G4
    UniProt: Q8N2G4

  • Chr Location
    2q21.2; chr2:132643286-132671579 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased fear and anxiety behaviors with increased spontaneous excitatory postsynaptic current following nicotine treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1315
  • Tissues
    181
  • cDNA Data
    9
  • Literature Summary
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026344 Ensembl Gene Model | MGI Sequence Detail 45480 C57BL/6J ±  kb
transcript ENSMUST00000159417 Ensembl | MGI Sequence Detail 6464 Not Applicable  
polypeptide ENSMUSP00000125149 Ensembl | MGI Sequence Detail 141 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 9
    Primer pair 2
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1924941, MGI:2138367
References
more
  • Summaries
    All 52
    Developmental Gene Expression 17
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:351382 Zhang D, et al., Lypd1-DTR/+: A New Mouse Model for Specifically Damaging the Type Ic Spiral Ganglion Neurons of the Cochlea. Neurosci Bull. 2023 Sep;39(9):1459-1462
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory