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Auts2 Gene Detail
Summary
  • Symbol
    Auts2
  • Name
    autism susceptibility candidate 2
  • Synonyms
    2700063G02Rik, A730011F23Rik, D830032G16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919847
    NCBI Gene: 319974
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:131466171-132572059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 70.66 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31386 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919847
 protein coding gene Chr5:131466171-132572183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030150
 protein coding gene Chr5:135676509-136816998 (-)
A/J MGP_AJ_G0030118
 protein coding gene Chr5:129907622-131021132 (-)
AKR/J MGP_AKRJ_G0030051
 protein coding gene Chr5:134134412-135264912 (-)
BALB/cJ MGP_BALBcJ_G0030128
 protein coding gene Chr5:131257434-132360744 (-)
C3H/HeJ MGP_C3HHeJ_G0029844
 protein coding gene Chr5:134713131-135811875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030581
 protein coding gene Chr5:140820033-141982929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027805
 protein coding gene Chr5:124280424-125380513 (-)
CAST/EiJ MGP_CASTEiJ_G0029253
 protein coding gene Chr5:134073351-135242313 (-)
CBA/J MGP_CBAJ_G0029814
 protein coding gene Chr5:146362879-147552642 (-)
DBA/2J MGP_DBA2J_G0029965
 protein coding gene Chr5:129861398-130961211 (-)
FVB/NJ MGP_FVBNJ_G0029920
 protein coding gene Chr5:128971437-130072676 (-)
LP/J MGP_LPJ_G0030053
 protein coding gene Chr5:136198510-137349567 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029952
 protein coding gene Chr5:149588448-150728769 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030621
 protein coding gene Chr5:133863300-134987302 (-)
PWK/PhJ MGP_PWKPhJ_G0028968
 protein coding gene Chr5:128852115-129958075 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028803
 protein coding gene Chr5:131440274-132574554 (-)
WSB/EiJ MGP_WSBEiJ_G0029327
 protein coding gene Chr5:134569066-135701054 (-)



Homology
more
  • Human Ortholog
    AUTS2, activator of transcription and developmental regulator AUTS2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AUTS2, activator of transcription and developmental regulator AUTS2
  • Synonyms
    FBRSL2, MRD26
  • Links
    NCBI Gene ID: 26053
    neXtProt AC: NX_Q8WXX7
    UniProt: Q8WXX7

  • Chr Location
    7q11.22; chr7:69598296-70793506 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Auts2 mouse models; 1 with human AUTS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a brain-specific knockout are smaller than controls, and exhibit behavioral defects such as less vocalizations, impairments in righting response and geotaxis, and decreased food intake.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    180
  • cDNA Data
    29
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      90
    • RefSeq
      2
    • UniProt
      12
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 319974 NCBI Gene Model | MGI Sequence Detail 1105889 C57BL/6J ±  kb
    transcript NM_001363480 RefSeq | MGI Sequence Detail 7291 Not Specified  
    polypeptide A0A087WPF7 UniProt | EBI | MGI Sequence Detail 1261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2442710, MGI:2443091
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:356508 Song Y, et al., Isolated loss of the AUTS2 long isoform, brain-wide or targeted to Calbindin-lineage cells, generates a specific suite of brain, behavioral, and molecular pathologies. Genetics. 2024 Jan 3;226(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory