Frmd4a Gene Detail

Summary

• Symbol
  Frmd4a
• Name
  FERM domain containing 4A
• Synonyms
  2700017I06Rik, C230040M21Rik, Gm13190, mKIAA1294

• Feature Type
  protein coding gene
• IDs
  MGI:1919850
  NCBI Gene: 209630
• Alliance
  gene page
• Transcription Start Sites
  46 TSS

Location &
Maps

• Sequence Map
  Chr2:4022528-4618854 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 2, 2.31 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  16687 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919850	protein coding gene	Chr2:4022461-4618854 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025313	protein coding gene	Chr2:1032056-1667083 (+)
A/J	MGP_AJ_G0025290	protein coding gene	Chr2:991750-1589768 (+)
AKR/J	MGP_AKRJ_G0025258	protein coding gene	Chr2:1007950-1622734 (+)
BALB/cJ	MGP_BALBcJ_G0025286	protein coding gene	Chr2:958346-1563624 (+)
C3H/HeJ	MGP_C3HHeJ_G0025046	protein coding gene	Chr2:993791-1611744 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025728	protein coding gene	Chr2:1033211-1679593 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023142	protein coding gene	Chr2:863718-1448287 (+)
CAST/EiJ	MGP_CASTEiJ_G0024509	protein coding gene	Chr2:989612-1612510 (+)
CBA/J	MGP_CBAJ_G0025025	protein coding gene	Chr2:1082374-1754332 (+)
DBA/2J	MGP_DBA2J_G0025157	protein coding gene	Chr2:959686-1561814 (+)
FVB/NJ	MGP_FVBNJ_G0025119	protein coding gene	Chr2:957980-1552952 (+)
LP/J	MGP_LPJ_G0025243	protein coding gene	Chr2:1023042-1643956 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025151	protein coding gene	Chr2:1037012-1666152 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025786	protein coding gene	Chr2:1000575-1620438 (+)
PWK/PhJ	MGP_PWKPhJ_G0024259	protein coding gene	Chr2:924858-1532779 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024060	protein coding gene	Chr2:996861-1634093 (+)
WSB/EiJ	MGP_WSBEiJ_G0024579	protein coding gene	Chr2:1006307-1632877 (+)

Homology

• Human Ortholog
  FRMD4A, FERM domain containing 4A

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FRMD4A, FERM domain containing 4A
  
• Synonyms
  bA295P9.4, CCAFCA, FRMD4
• Links
  HGNC:25491

  NCBI Gene ID: 55691

  neXtProt AC: NX_Q9P2Q2

  UniProt: Q9P2Q2

  
  
• Chr Location
  10p13; chr10:13643706-14462142 (-)  GRCh38

---

• MGI Vertebrate Homology
  Frmd4a stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FRMD4A
• Gene Tree
  Frmd4a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  6 phenotype references
  

• All Mutations and Alleles
  13
• Endonuclease-mediated
  1
• Gene trapped
  12
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  91 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  6

Expression

• Assay Results
  749
• Tissues
  14
• cDNA Data
  16
• Literature Summary
  5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase frmd4a

Sequences &
Gene Models

• All Sequences
  120
• RefSeq
  28
• UniProt
  10
• CCDS
  CCDS15656.2, CCDS50488.1, CCDS57151.1, CCDS84466.1

• Ensembl
  ENSMUSG00000026657 (Evidence)
• NCBI Gene
  209630

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000026657	Ensembl Gene Model | MGI Sequence Detail	596327	C57BL/6J
transcript	ENSMUST00000091497	Ensembl | MGI Sequence Detail	6208	Not Applicable
polypeptide	ENSMUSP00000089079	Ensembl | MGI Sequence Detail	1042	Not Applicable

Protein
Information

• UniProt
  10 Sequences
• Protein Ontology
  PR:000030675 FERM domain-containing protein 4A
  (term hierarchy)
• InterPro Domains
  IPR019749 Band 4.1 domain
  IPR021774 Cytohesin Ubiquitin Protein Inducing Domain
  IPR014352 FERM/acyl-CoA-binding protein superfamily
  IPR019748 FERM central domain
  IPR019747 FERM conserved site
  IPR018980 FERM, C-terminal PH-like domain
  IPR000299 FERM domain
  IPR047176 FERM domain-containing protein 4A/B
  IPR018979 FERM, N-terminal
  IPR035963 FERM superfamily, second domain
  IPR041785 FRMD4A/B, FERM domain C-lobe
  IPR011993 PH-like domain superfamily
  IPR029071 Ubiquitin-like domain superfamily
• GlyGen
  Q8BIE6 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

Molecular
Reagents

• All nucleic 19

  cDNA 17

  Primer pair 2

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2139010, MGI:2443045, MGI:3711984

References

• Summaries
  All 39

  Developmental Gene Expression 5

  Gene Ontology 6

  Phenotypes 6
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Frmd4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr390	Chr2:4022496-4022507 (+)	-26 bp
Tssr15926	Chr2:4022517-4022533 (+)	-3 bp
Tssr15927	Chr2:4022538-4022556 (+)	19 bp
Tssr15928	Chr2:4022568-4022579 (+)	46 bp
Tssr15929	Chr2:4062719-4062730 (+)	40,197 bp
Tssr15930	Chr2:4062915-4062945 (+)	40,402 bp
Tssr15931	Chr2:4136470-4136475 (+)	113,945 bp
Tssr15933	Chr2:4157399-4157421 (+)	134,882 bp
Tssr15934	Chr2:4157426-4157455 (+)	134,913 bp
Tssr15935	Chr2:4170775-4170780 (+)	148,250 bp
Tssr15937	Chr2:4290047-4290064 (+)	267,528 bp
Tssr15938	Chr2:4305273-4305333 (+)	282,775 bp
Tssr15939	Chr2:4305348-4305379 (+)	282,836 bp
Tssr15940	Chr2:4305401-4305410 (+)	282,878 bp
Tssr15941	Chr2:4305415-4305428 (+)	282,894 bp
Tssr15942	Chr2:4305434-4305446 (+)	282,912 bp
Tssr15943	Chr2:4305538-4305552 (+)	283,017 bp
Tssr15944	Chr2:4305560-4305576 (+)	283,040 bp
Tssr15945	Chr2:4305584-4305608 (+)	283,068 bp
Tssr15946	Chr2:4305688-4305715 (+)	283,174 bp
Tssr15947	Chr2:4305719-4305742 (+)	283,203 bp
Tssr15948	Chr2:4394266-4394278 (+)	371,744 bp
Tssr15949	Chr2:4394405-4394413 (+)	371,881 bp
Tssr15950	Chr2:4394426-4394450 (+)	371,910 bp
Tssr15951	Chr2:4404056-4404060 (+)	381,530 bp
Tssr15952	Chr2:4405609-4405639 (+)	383,096 bp
Tssr15953	Chr2:4405769-4405780 (+)	383,247 bp
Tssr15954	Chr2:4405907-4405931 (+)	383,391 bp
Tssr15955	Chr2:4405971-4405983 (+)	383,449 bp
Tssr15956	Chr2:4406102-4406143 (+)	383,595 bp
Tssr15957	Chr2:4406204-4406311 (+)	383,730 bp
Tssr15958	Chr2:4406316-4406335 (+)	383,798 bp
Tssr15959	Chr2:4406350-4406367 (+)	383,831 bp
Tssr15960	Chr2:4421098-4421130 (+)	398,586 bp
Tssr15961	Chr2:4436757-4436808 (+)	414,255 bp
Tssr15962	Chr2:4564413-4564440 (+)	541,899 bp
Tssr15963	Chr2:4564456-4564467 (+)	541,934 bp
Tssr15964	Chr2:4564512-4564517 (+)	541,987 bp
Tssr15965	Chr2:4564553-4564566 (+)	542,032 bp
Tssr15966	Chr2:4564570-4564621 (+)	542,068 bp
Tssr15967	Chr2:4564689-4564703 (+)	542,168 bp
Tssr15968	Chr2:4564724-4564741 (+)	542,205 bp
Tssr15969	Chr2:4564742-4564754 (+)	542,220 bp
Tssr15970	Chr2:4564861-4564874 (+)	542,340 bp
Tssr15971	Chr2:4564929-4564959 (+)	542,416 bp
Tssr15972	Chr2:4602077-4602102 (+)	579,562 bp