Anks3 MGI Mouse Gene Detail - MGI:1919865 - ankyrin repeat and sterile alpha motif domain containing 3

Symbol

Anks3
Name

ankyrin repeat and sterile alpha motif domain containing 3
Synonyms

2700067D09Rik, mKIAA1977

Feature Type

protein coding gene
IDs

MGI:1919865
NCBI Gene: 72615
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:4759300-4782069 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.48 cM, cytoband A1
Mapping Data

4 experiments

SNPs within 2kb

572 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919865	protein coding gene	Chr16:4759290-4783362 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022477	protein coding gene	Chr16:1460700-1484132 (-)
A/J	MGP_AJ_G0022439	protein coding gene	Chr16:1271782-1295577 (-)
AKR/J	MGP_AKRJ_G0022416	protein coding gene	Chr16:1465953-1489869 (-)
BALB/cJ	MGP_BALBcJ_G0022444	protein coding gene	Chr16:1426522-1449019 (-)
C3H/HeJ	MGP_C3HHeJ_G0022211	protein coding gene	Chr16:1487288-1511142 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022893	protein coding gene	Chr16:1548163-1571684 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020414	protein coding gene	Chr16:1196150-1220414 (-)
CAST/EiJ	MGP_CASTEiJ_G0021737	protein coding gene	Chr16:1492345-1515749 (-)
CBA/J	MGP_CBAJ_G0022180	protein coding gene	Chr16:1623853-1658987 (-)
DBA/2J	MGP_DBA2J_G0022311	protein coding gene	Chr16:1376439-1399263 (-)
FVB/NJ	MGP_FVBNJ_G0022286	protein coding gene	Chr16:1371339-1393494 (-)
LP/J	MGP_LPJ_G0022379	protein coding gene	Chr16:1450896-1474952 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022308	protein coding gene	Chr16:1481283-1506705 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022905	protein coding gene	Chr16:1440012-1463453 (-)
PWK/PhJ	MGP_PWKPhJ_G0021477	protein coding gene	Chr16:1449311-1472431 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021308	protein coding gene	Chr16:1528567-1552074 (-)
WSB/EiJ	MGP_WSBEiJ_G0021786	protein coding gene	Chr16:1452487-1478783 (-)

Human Ortholog

ANKS3, ankyrin repeat and sterile alpha motif domain containing 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKS3, ankyrin repeat and sterile alpha motif domain containing 3
Links

HGNC:29422

NCBI Gene ID: 124401

neXtProt AC: NX_Q6ZW76

UniProt: Q6ZW76
Chr Location

16p13.3; chr16:4696510-4734378 (-) GRCh38

MGI Vertebrate Homology

Anks3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANKS3
Gene Tree

Anks3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

10
cDNA Data

50
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase anks3

ZFIN anks3

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All Sequences

120
RefSeq

46
UniProt

7
CCDS

CCDS27928.1

Ensembl

ENSMUSG00000022515 (Evidence)
NCBI Gene

72615

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022515	Ensembl Gene Model \| MGI Sequence Detail	22770	C57BL/6J	± kb
transcript	ENSMUST00000023157	Ensembl \| MGI Sequence Detail	2398	Not Applicable
polypeptide	ENSMUSP00000023157	Ensembl \| MGI Sequence Detail	655	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031483 ankyrin repeat and SAM domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR047238 Ankyrin repeat and SAM domain-containing protein 3, SAM domain

IPR036770 Ankyrin repeat-containing domain superfamily

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 51

cDNA 51

Microarray probesets 5

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MGI:2146713

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Anks3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139818	Chr16:4782032-4782084 (-)	11 bp
Tssr4780	Chr16:4781876-4781881 (-)	190 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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