Lins1 Gene Detail

Summary

• Symbol
  Lins1
• Name
  lines homolog 1
• Synonyms
  2700083B01Rik, Lins, Wins2

• Feature Type
  protein coding gene
• IDs
  MGI:1919885
  NCBI Gene: 72635
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr7:66339637-66367004 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 36.08 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  797 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919885	protein coding gene	Chr7:66339565-66367004 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032354	protein coding gene	Chr7:67923153-67950751 (+)
A/J	MGP_AJ_G0032333	protein coding gene	Chr7:66527380-66554300 (+)
AKR/J	MGP_AKRJ_G0032269	protein coding gene	Chr7:67943154-67971126 (+)
BALB/cJ	MGP_BALBcJ_G0032345	protein coding gene	Chr7:66267757-66295082 (+)
C3H/HeJ	MGP_C3HHeJ_G0032058	protein coding gene	Chr7:68614073-68641328 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032837	protein coding gene	Chr7:70835499-70867071 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029844	protein coding gene	Chr7:69422829-69449148 (+)
CAST/EiJ	MGP_CASTEiJ_G0031386	protein coding gene	Chr7:59296176-59328273 (+)
CBA/J	MGP_CBAJ_G0032024	protein coding gene	Chr7:73050859-73079827 (+)
DBA/2J	MGP_DBA2J_G0032179	protein coding gene	Chr7:65248985-65278142 (+)
FVB/NJ	MGP_FVBNJ_G0032134	protein coding gene	Chr7:65375474-65402642 (+)
LP/J	MGP_LPJ_G0032260	protein coding gene	Chr7:69140273-69174654 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032171	protein coding gene	Chr7:73291214-73320131 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032855	protein coding gene	Chr7:67296038-67326873 (+)
PWK/PhJ	MGP_PWKPhJ_G0031106	protein coding gene	Chr7:58290967-58320207 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030947	protein coding gene	Chr7:54336067-54367872 (+)
WSB/EiJ	MGP_WSBEiJ_G0031504	protein coding gene	Chr7:67641277-67672161 (+)

Homology

• Human Ortholog
  LINS1, lines homolog 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  LINS1, lines homolog 1
  
• Synonyms
  LINS, MRT27, WINS1
• Links
  HGNC:30922

  NCBI Gene ID: 55180

  neXtProt AC: NX_Q8NG48

  UniProt: Q8NG48

  
  
• Chr Location
  15q26.3; chr15:100559369-100603230 (-)  GRCh38

---

• MGI Vertebrate Homology
  Lins1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: LINS1
• Gene Tree
  Lins1
  

Human Diseases

• Diseases
  1 with human LINS1 associations

				Human Disease	Mouse Models
				autosomal recessive intellectual developmental disorder 27 IDs autosomal recessive intellectual developmental disorder 27       DOID:0081193 OMIM:614340

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 1 genetic background
  16 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  3
• Radiation induced
  1
• Genomic Mutations
  2 involving Lins1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  25 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  39

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase lins1

Sequences &
Gene Models

• All Sequences
  97
• RefSeq
  31
• UniProt
  8
• CCDS
  CCDS21348.2, CCDS57555.1

• Ensembl
  ENSMUSG00000053091 (Evidence)
• NCBI Gene
  72635

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000053091	Ensembl Gene Model | MGI Sequence Detail	27368	C57BL/6J
transcript	ENSMUST00000121777	Ensembl | MGI Sequence Detail	2729	Not Applicable
polypeptide	ENSMUSP00000112404	Ensembl | MGI Sequence Detail	764	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• Protein Ontology
  PR:000009831 protein Lines homolog 1
  (term hierarchy)
• InterPro Domains
  IPR024875 Protein Lines
  IPR029415 Protein Lines, C-terminal
  IPR032794 Protein Lines, N-terminal

Molecular
Reagents

• All nucleic 39

  cDNA 39

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2142255

References

• Summaries
  All 41

  Gene Ontology 2

  Phenotypes 16
• Earliest
  J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lins1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67066	Chr7:66339663-66339728 (+)	59 bp