Serp2 MGI Mouse Gene Detail - MGI:1919911 - stress-associated endoplasmic reticulum protein family member 2

Symbol

Serp2
Name

stress-associated endoplasmic reticulum protein family member 2
Synonyms

2810032E02Rik

Feature Type

protein coding gene
IDs

MGI:1919911
NCBI Gene: 72661
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:76770254-76794329 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 40.44 cM
Mapping Data

1 experiment

SNPs within 2kb

617 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919911	protein coding gene	Chr14:76770252-76794518 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021581	protein coding gene	Chr14:71472186-71496170 (-)
A/J	MGP_AJ_G0021539	protein coding gene	Chr14:69807405-69831336 (-)
AKR/J	MGP_AKRJ_G0021516	protein coding gene	Chr14:71890865-71914736 (-)
BALB/cJ	MGP_BALBcJ_G0021546	protein coding gene	Chr14:69614502-69638726 (-)
C3H/HeJ	MGP_C3HHeJ_G0021323	protein coding gene	Chr14:71609969-71633838 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021986	protein coding gene	Chr14:74574670-74599903 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019524	protein coding gene	Chr14:67405090-67428997 (-)
CAST/EiJ	MGP_CASTEiJ_G0020840	protein coding gene	Chr14:68322615-68346459 (-)
CBA/J	MGP_CBAJ_G0021291	protein coding gene	Chr14:76975132-76999162 (-)
DBA/2J	MGP_DBA2J_G0021414	protein coding gene	Chr14:69206592-69230644 (-)
FVB/NJ	MGP_FVBNJ_G0021392	protein coding gene	Chr14:68551854-68575755 (-)
LP/J	MGP_LPJ_G0021484	protein coding gene	Chr14:72595727-72619671 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021419	protein coding gene	Chr14:75656587-75680461 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022009	protein coding gene	Chr14:71168006-71191910 (-)
PWK/PhJ	MGP_PWKPhJ_G0020583	protein coding gene	Chr14:65966356-65990272 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020420	protein coding gene	Chr14:67129874-67153674 (-)
WSB/EiJ	MGP_WSBEiJ_G0020893	protein coding gene	Chr14:71522260-71546970 (-)

Human Ortholog

SERP2, stress associated endoplasmic reticulum protein family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERP2, stress associated endoplasmic reticulum protein family member 2
Synonyms

bA269C23.1, C13orf21
Links

HGNC:20607

NCBI Gene ID: 387923

neXtProt AC: NX_Q8N6R1

UniProt: Q8N6R1
Chr Location

13q14.11; chr13:44373647-44397714 (+) GRCh38

MGI Vertebrate Homology

Serp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SERP2
Gene Tree

Serp2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

7
Targeted

3
Genomic Mutations

1 involving Serp2
Find Mice (IMSR)

8 strains or lines available

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase serp2

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All Sequences

56
RefSeq

12
UniProt

3
CCDS

CCDS49546.1

Ensembl

ENSMUSG00000052584 (Evidence)
NCBI Gene

72661

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052584	Ensembl Gene Model \| MGI Sequence Detail	24076	C57BL/6J	± kb
transcript	ENSMUST00000064517	Ensembl \| MGI Sequence Detail	748	Not Applicable
polypeptide	ENSMUSP00000068508	Ensembl \| MGI Sequence Detail	65	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014677 stress-associated endoplasmic reticulum protein 2

(term hierarchy)
InterPro Domains

IPR010580 Stress-associated endoplasmic reticulum protein

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All nucleic 19

cDNA 19

Microarray probesets 3

Summaries

All 31

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Serp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129818	Chr14:76794347-76794358 (-)	-24 bp
Tssr129817	Chr14:76794323-76794330 (-)	2 bp
Tssr4484	Chr14:76794294-76794305 (-)	29 bp
Tssr129816	Chr14:76794102-76794156 (-)	200 bp
Tssr129815	Chr14:76794082-76794093 (-)	241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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