Usp24 MGI Mouse Gene Detail - MGI:1919936 - ubiquitin specific peptidase 24

Symbol

Usp24
Name

ubiquitin specific peptidase 24
Synonyms

2700066K03Rik, 2810030C21Rik

Feature Type

protein coding gene
IDs

MGI:1919936
NCBI Gene: 329908
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:106173417-106298519 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 49.44 cM, cytoband C7
Mapping Data

3 experiments

SNPs within 2kb

2632 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919936	protein coding gene	Chr4:106173179-106303798 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028517	protein coding gene	Chr4:106924776-107053120 (+)
A/J	MGP_AJ_G0028480	protein coding gene	Chr4:103120999-103245052 (+)
AKR/J	MGP_AKRJ_G0028427	protein coding gene	Chr4:105619524-105748444 (+)
BALB/cJ	MGP_BALBcJ_G0028499	protein coding gene	Chr4:103306815-103431552 (+)
C3H/HeJ	MGP_C3HHeJ_G0028213	protein coding gene	Chr4:106377944-106500341 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028939	protein coding gene	Chr4:110808092-110935668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026230	protein coding gene	Chr4:98385165-98511081 (+)
CAST/EiJ	MGP_CASTEiJ_G0027649	protein coding gene	Chr4:104174797-104296453 (+)
CBA/J	MGP_CBAJ_G0028182	protein coding gene	Chr4:114371299-114506243 (+)
DBA/2J	MGP_DBA2J_G0028330	protein coding gene	Chr4:102736438-102861312 (+)
FVB/NJ	MGP_FVBNJ_G0028298	protein coding gene	Chr4:101590611-101716986 (+)
LP/J	MGP_LPJ_G0028431	protein coding gene	Chr4:107128507-107258433 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028324	protein coding gene	Chr4:119721212-119849068 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028975	protein coding gene	Chr4:105871892-105997060 (+)
PWK/PhJ	MGP_PWKPhJ_G0027375	protein coding gene	Chr4:100962047-101106639 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027199	protein coding gene	Chr4:103254571-103381369 (+)
WSB/EiJ	MGP_WSBEiJ_G0027730	protein coding gene	Chr4:106046839-106172778 (+)

Human Ortholog

USP24, ubiquitin specific peptidase 24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP24, ubiquitin specific peptidase 24
Links

HGNC:12623

NCBI Gene ID: 23358

neXtProt AC: NX_Q9UPU5

UniProt: Q9UPU5
Chr Location

1p32.3; chr1:55066359-55215378 (-) GRCh38

MGI Vertebrate Homology

Usp24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: USP24
Gene Tree

Usp24

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

11
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Usp24
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

108 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with a catalytically-inactive allele show neonatal lethality while aged heterozygotes show increased incidence of tumors and increased DMBA-induced tumors.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

1
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase usp24

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All Sequences

53
RefSeq

14
UniProt

2
CCDS

CCDS51251.1

Ensembl

ENSMUSG00000028514 (Evidence)
NCBI Gene

329908

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028514	Ensembl Gene Model \| MGI Sequence Detail	125103	C57BL/6J	± kb
transcript	ENSMUST00000094933	Ensembl \| MGI Sequence Detail	10635	Not Applicable
polypeptide	ENSMUSP00000092538	Ensembl \| MGI Sequence Detail	2637	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017162 ubiquitin carboxyl-terminal hydrolase 24

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR016024 Armadillo-type fold

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR009060 UBA-like superfamily

IPR015940 Ubiquitin-associated domain

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR029071 Ubiquitin-like domain superfamily

IPR033382 Ubiquitin-specific peptidase 24, UBA domain

IPR047061 Ubiquitin-specific peptidase 24, ubiquitin-like domain

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain
GlyGen

B1AY13 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 13

cDNA 13

Microarray probesets 8

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MGI:1919673, MGI:2140254, MGI:2140682

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 19
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:348295 Young MJ, et al., USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy. Cell Death Differ. 2024 May;31(5):574-591

TSS for Usp24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38169	Chr4:106173193-106173243 (+)	-199 bp
Tssr38170	Chr4:106173246-106173267 (+)	-160 bp
Tssr38171	Chr4:106173274-106173316 (+)	-122 bp
Tssr38172	Chr4:106173319-106173336 (+)	-89 bp
Tssr38173	Chr4:106173384-106173440 (+)	-5 bp
Tssr38174	Chr4:106173498-106173525 (+)	95 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24