C1qtnf6 MGI Mouse Gene Detail - MGI:1919959 - C1q and tumor necrosis factor related protein 6

Symbol

C1qtnf6
Name

C1q and tumor necrosis factor related protein 6
Synonyms

2810036M19Rik, CTRP6

Feature Type

protein coding gene
IDs

MGI:1919959
NCBI Gene: 72709
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:78407546-78415616 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.55 cM
Mapping Data

2 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919959	protein coding gene	Chr15:78407546-78416370 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022046	protein coding gene	Chr15:78720941-78727219 (-)
A/J	MGP_AJ_G0022007	protein coding gene	Chr15:76022236-76028536 (-)
AKR/J	MGP_AKRJ_G0021982	protein coding gene	Chr15:78112290-78118576 (-)
BALB/cJ	MGP_BALBcJ_G0022013	protein coding gene	Chr15:75995413-76001693 (-)
C3H/HeJ	MGP_C3HHeJ_G0021784	protein coding gene	Chr15:78128768-78135055 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022456	protein coding gene	Chr15:81821430-81827709 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019986	protein coding gene	Chr15:72520948-72527318 (-)
CAST/EiJ	MGP_CASTEiJ_G0021305	protein coding gene	Chr15:78811619-78817920 (-)
CBA/J	MGP_CBAJ_G0021749	protein coding gene	Chr15:84343580-84351114 (-)
DBA/2J	MGP_DBA2J_G0021878	protein coding gene	Chr15:75507115-75513392 (-)
FVB/NJ	MGP_FVBNJ_G0021856	protein coding gene	Chr15:74511041-74517319 (-)
LP/J	MGP_LPJ_G0021946	protein coding gene	Chr15:78928708-78935013 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021876	protein coding gene	Chr15:89540984-89547294 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022470	protein coding gene	Chr15:78155976-78162285 (-)
PWK/PhJ	MGP_PWKPhJ_G0021047	protein coding gene	Chr15:75506198-75512508 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020884	protein coding gene	Chr15:77930471-77936785 (-)
WSB/EiJ	MGP_WSBEiJ_G0021357	protein coding gene	Chr15:78512701-78519004 (-)

Human Ortholog

C1QTNF6, C1q and TNF related 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QTNF6, C1q and TNF related 6
Synonyms

CTFP6, CTRP6, ZACRP6
Links

HGNC:14343

NCBI Gene ID: 114904

neXtProt AC: NX_Q9BXI9

UniProt: Q9BXI9
Chr Location

22q12.3; chr22:37180166-37199423 (-) GRCh38

MGI Vertebrate Homology

C1qtnf6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: C1QTNF6
Gene Tree

C1qtnf6

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 1 allele in 2 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving C1qtnf6
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show partial prenatal lethality, increased autoantibody levels, enhanced complement activation, and increased susceptibility to induced arthritis, experimental autoimmune encephalomyelitis and type III hypersensitivity reaction.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

55

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

62
RefSeq

16
UniProt

5
CCDS

CCDS37134.1, CCDS88801.1

Ensembl

ENSMUSG00000022440 (Evidence)
NCBI Gene

72709

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022440	Ensembl Gene Model \| MGI Sequence Detail	8071	C57BL/6J	± kb
transcript	ENSMUST00000023075	Ensembl \| MGI Sequence Detail	2402	Not Applicable
polypeptide	ENSMUSP00000023075	Ensembl \| MGI Sequence Detail	264	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004888 complement C1q tumor necrosis factor-related protein 6

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050822 Cerebellin Synaptic Organizer

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q6IR41 1 site, 1 N-linked glycan (1 site)

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All nucleic 55

cDNA 55

Microarray probesets 4

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MGI:2145996, MGI:2146250

Summaries

All 58

Diseases 1

Gene Ontology 4

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:349739 Xu C, et al., CTRP6 promotes the macrophage inflammatory response, and its deficiency attenuates LPS-induced inflammation. J Biol Chem. 2023 Dec 14;300(1):105566

TSS for C1qtnf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135237	Chr15:78413842-78413861 (-)	1,764 bp
Tssr135236	Chr15:78413817-78413836 (-)	1,789 bp
Tssr135235	Chr15:78413809-78413812 (-)	1,805 bp
Tssr135234	Chr15:78413780-78413805 (-)	1,823 bp
Tssr135233	Chr15:78413759-78413770 (-)	1,851 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24