B3gat3 MGI Mouse Gene Detail - MGI:1919977 - beta-1,3-glucuronyltransferase 3

Symbol

B3gat3
Name

beta-1,3-glucuronyltransferase 3
Synonyms

2810405M13Rik, GlcAT-I

Feature Type

protein coding gene
IDs

MGI:1919977
NCBI Gene: 72727
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:8897740-8904600 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 6.03 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

171 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919977	protein coding gene	Chr19:8897738-8904600 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024822	protein coding gene	Chr19:6207841-6214956 (+)
A/J	MGP_AJ_G0024790	protein coding gene	Chr19:5873211-5880069 (+)
AKR/J	MGP_AKRJ_G0024765	protein coding gene	Chr19:5969111-5978027 (+)
BALB/cJ	MGP_BALBcJ_G0024790	protein coding gene	Chr19:5981102-5989303 (+)
C3H/HeJ	MGP_C3HHeJ_G0024556	protein coding gene	Chr19:6057804-6066223 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025237	protein coding gene	Chr19:6343915-6350469 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022666	protein coding gene	Chr19:6130460-6137149 (+)
CAST/EiJ	MGP_CASTEiJ_G0024029	protein coding gene	Chr19:5708483-5715908 (+)
CBA/J	MGP_CBAJ_G0024530	protein coding gene	Chr19:6461494-6468301 (+)
DBA/2J	MGP_DBA2J_G0024657	protein coding gene	Chr19:5707821-5714860 (+)
FVB/NJ	MGP_FVBNJ_G0024624	protein coding gene	Chr19:5778292-5785108 (+)
LP/J	MGP_LPJ_G0024744	protein coding gene	Chr19:6101622-6110692 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024651	protein coding gene	Chr19:6318171-6326558 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025286	protein coding gene	Chr19:6015331-6025592 (+)
PWK/PhJ	MGP_PWKPhJ_G0023774	protein coding gene	Chr19:5380484-5387700 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023579	protein coding gene	Chr19:5629339-5636278 (+)
WSB/EiJ	MGP_WSBEiJ_G0024091	protein coding gene	Chr19:5986386-5993194 (+)

Human Ortholog

B3GAT3, beta-1,3-glucuronyltransferase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B3GAT3, beta-1,3-glucuronyltransferase 3
Synonyms

GLCATI, glcUAT-I, JDSCD
Links

HGNC:923

NCBI Gene ID: 26229

neXtProt AC: NX_O94766

UniProt: O94766
Chr Location

11q12.3; chr11:62615296-62622154 (-) GRCh38

MGI Vertebrate Homology

B3gat3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B3GAT3
Gene Tree

B3gat3

Diseases

1 with human B3GAT3 associations

				Human Disease	Mouse Models
				Larsen-like syndrome B3GAT3 type IDs Larsen-like syndrome B3GAT3 type DOID:0080575 OMIM:245600 ORDO:284139

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants die prenatally before the 8-cell stage due to failed cytokinesis, and show reduction of the synthesis of chondroitin sulfate and heparan sulfate glycosaminoglycans.

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

60
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase b3gat3

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All Sequences

50
RefSeq

3
UniProt

6
CCDS

CCDS29558.1

Ensembl

ENSMUSG00000071649 (Evidence)
NCBI Gene

72727

			Length	Strain/Species	Flank
genomic	72727	NCBI Gene Model \| MGI Sequence Detail	6861	C57BL/6J	± kb
transcript	NM_024256	RefSeq \| MGI Sequence Detail	1599	C57BL/6
polypeptide	P58158	UniProt \| EBI \| MGI Sequence Detail	335	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004590 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

(term hierarchy)
EC

2.4.1.135
InterPro Domains

IPR005027 Glycosyl transferase, family 43

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

P58158 1 site, 1 N-linked glycan (1 site)

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All nucleic 62

Genomic 1

cDNA 61

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 8
Earliest

J:324228 Kitagawa H, et al., Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 1998 Mar 20;273(12):6615-8
Latest

J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565

TSS for B3gat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154878	Chr19:8897722-8897790 (+)	16 bp
Tssr154879	Chr19:8897796-8897810 (+)	63 bp
Tssr154880	Chr19:8897825-8897837 (+)	91 bp
Tssr154881	Chr19:8897860-8897939 (+)	160 bp
Tssr154882	Chr19:8899421-8899438 (+)	1,690 bp
Tssr154883	Chr19:8899488-8899500 (+)	1,754 bp
Tssr154884	Chr19:8904287-8904290 (+)	6,549 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24