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Tmem135 Gene Detail
Summary
  • Symbol
    Tmem135
  • Name
    transmembrane protein 135
  • Synonyms
    2810439K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920009
    NCBI Gene: 72759
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:88788922-89053430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 49.32 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5848 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J no annotation
129S1/SvImJ MGP_129S1SvImJ_G0032494
 protein coding gene Chr7:91544013-91814195 (-)
A/J MGP_AJ_G0032468
 protein coding gene Chr7:89365002-89621257 (-)
AKR/J MGP_AKRJ_G0032404
 protein coding gene Chr7:91437601-91697651 (-)
BALB/cJ MGP_BALBcJ_G0032479
 protein coding gene Chr7:89005622-89266992 (-)
C3H/HeJ MGP_C3HHeJ_G0032194
 protein coding gene Chr7:91831642-92102601 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032977
 protein coding gene Chr7:95095363-95369484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029972
 protein coding gene Chr7:92288741-92537755 (-)
CAST/EiJ MGP_CASTEiJ_G0031521
 protein coding gene Chr7:83268870-83537814 (-)
CBA/J MGP_CBAJ_G0032161
 protein coding gene Chr7:98279355-98557718 (-)
DBA/2J MGP_DBA2J_G0032313
 protein coding gene Chr7:87790105-88051473 (-)
FVB/NJ MGP_FVBNJ_G0032269
 protein coding gene Chr7:87665405-87924547 (-)
LP/J MGP_LPJ_G0032402
 protein coding gene Chr7:92785201-93049403 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032303
 protein coding gene Chr7:99327433-99611466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032999
 protein coding gene Chr7:90715296-90994198 (-)
PWK/PhJ MGP_PWKPhJ_G0031239
 protein coding gene Chr7:80810933-81067233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031082
 protein coding gene Chr7:78036397-78310897 (-)
WSB/EiJ MGP_WSBEiJ_G0031638
 protein coding gene Chr7:91346609-91607104 (-)



Homology
more
  • Human Ortholog
    TMEM135, transmembrane protein 135
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM135, transmembrane protein 135
  • Synonyms
    PMP52
  • Links
    NCBI Gene ID: 65084
    neXtProt AC: NX_Q86UB9
    UniProt: Q86UB9

  • Chr Location
    11q14.2; chr11:87037844-87328824 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozgous for an ENU-induced allele exhibit age-dependent retinal pathologies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039428 Ensembl Gene Model | MGI Sequence Detail 264509 C57BL/6J ±  kb
    transcript ENSMUST00000041968 Ensembl | MGI Sequence Detail 3700 Not Applicable  
    polypeptide ENSMUSP00000042783 Ensembl | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 83

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142228
    References
    more
    • Summaries
      All 69
      Gene Ontology 8
      Phenotypes 42
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:360080 Liu J, et al., TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics. Metabolism. 2023 Dec 26;152:155767
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory