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Neil1 Gene Detail
Summary
  • Symbol
    Neil1
  • Name
    nei endonuclease VIII-like 1 (E. coli)
  • Synonyms
    2810450N13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920024
    NCBI Gene: 72774
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57050084-57055589 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.89 cM, cytoband C
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920024
 protein coding gene Chr9:57050072-57055973 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034860
 protein coding gene Chr9:56311790-56317299 (-)
A/J MGP_AJ_G0034841
 protein coding gene Chr9:54500463-54505976 (-)
AKR/J MGP_AKRJ_G0034770
 protein coding gene Chr9:55759007-55764023 (-)
BALB/cJ MGP_BALBcJ_G0034833
 protein coding gene Chr9:54302162-54307667 (-)
C3H/HeJ MGP_C3HHeJ_G0034543
 protein coding gene Chr9:56231394-56236907 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035352
 protein coding gene Chr9:57902047-57906681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032263
 protein coding gene Chr9:53839362-53845163 (-)
CAST/EiJ MGP_CASTEiJ_G0033864
 protein coding gene Chr9:56312243-56317747 (-)
CBA/J MGP_CBAJ_G0034514
 protein coding gene Chr9:59922529-59928040 (-)
DBA/2J MGP_DBA2J_G0034673
 protein coding gene Chr9:54381402-54386911 (-)
FVB/NJ MGP_FVBNJ_G0034615
 protein coding gene Chr9:53603939-53609448 (-)
LP/J MGP_LPJ_G0034756
 protein coding gene Chr9:56605421-56610930 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034658
 protein coding gene Chr9:61399092-61404601 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035374
 protein coding gene Chr9:55774595-55780108 (-)
PWK/PhJ MGP_PWKPhJ_G0033569
 protein coding gene Chr9:54411119-54416631 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033403
 protein coding gene Chr9:56066357-56071893 (-)
WSB/EiJ MGP_WSBEiJ_G0033977
 protein coding gene Chr9:55711930-55717443 (-)



Homology
more
  • Human Ortholog
    NEIL1, nei like DNA glycosylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEIL1, nei like DNA glycosylase 1
  • Synonyms
    FPG1, hFPG1, NEI1
  • Links
    NCBI Gene ID: 79661
    neXtProt AC: NX_Q96FI4
    UniProt: Q96FI4

  • Chr Location
    15q24.2; chr15:75346955-75357115 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Neil1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop severe obesity, dyslipidemia, fatty liver disease and tend to show hyperinsulinemia and increased mtDNA damage and deletions. Sporadic phenotypes include reduced subcutaneous fat, skin ulcers, joint inflammation, infertility,and tumors. Male heterozygotes become obese.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    7
  • cDNA Data
    6
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032298 Ensembl Gene Model | MGI Sequence Detail 5506 C57BL/6J ±  kb
    transcript ENSMUST00000190245 Ensembl | MGI Sequence Detail 1693 Not Applicable  
    polypeptide ENSMUSP00000139917 Ensembl | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory