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Fance Gene Detail
Summary
  • Symbol
    Fance
  • Name
    Fanconi anemia, complementation group E
  • Synonyms
    2810451D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920025
    NCBI Gene: 72775
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28532504-28545548 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920025
 protein coding gene Chr17:28532493-28545548 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023437
 protein coding gene Chr17:27700508-27715082 (+)
A/J MGP_AJ_G0023395
 protein coding gene Chr17:26795080-26808091 (+)
AKR/J MGP_AKRJ_G0023360
 protein coding gene Chr17:26991493-27004493 (+)
BALB/cJ MGP_BALBcJ_G0023400
 protein coding gene Chr17:27061991-27075019 (+)
C3H/HeJ MGP_C3HHeJ_G0023161
 protein coding gene Chr17:27372270-27386467 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023842
 protein coding gene Chr17:28819714-28833559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021317
 protein coding gene Chr17:24167269-24180556 (+)
CAST/EiJ MGP_CASTEiJ_G0022662
 protein coding gene Chr17:27349582-27365805 (+)
CBA/J MGP_CBAJ_G0023135
 protein coding gene Chr17:29842127-29859493 (+)
DBA/2J MGP_DBA2J_G0023266
 protein coding gene Chr17:26348927-26362213 (+)
FVB/NJ MGP_FVBNJ_G0023236
 protein coding gene Chr17:26154880-26169736 (+)
LP/J MGP_LPJ_G0023344
 protein coding gene Chr17:27953301-27967904 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023254
 protein coding gene Chr17:29276423-29295501 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023884
 protein coding gene Chr17:27409598-27424085 (+)
PWK/PhJ MGP_PWKPhJ_G0022412
 protein coding gene Chr17:25157111-25170392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022230
 protein coding gene Chr17:25419503-25432249 (+)
WSB/EiJ MGP_WSBEiJ_G0022724
 protein coding gene Chr17:27409024-27423731 (+)



Homology
more
  • Human Ortholog
    FANCE, FA complementation group E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANCE, FA complementation group E
  • Synonyms
    FACE, FAE
  • Links
    NCBI Gene ID: 2178
    neXtProt AC: NX_Q9HB96
    UniProt: Q9HB96

  • Chr Location
    6p21.31; chr6:35452338-35467104 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FANCE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout causes reduced male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    11
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72775 NCBI Gene Model | MGI Sequence Detail 13045 C57BL/6J ±  kb
    transcript NM_001163819 RefSeq | MGI Sequence Detail 2016 C57BL/6  
    polypeptide NP_001157291 RefSeq | MGI Sequence Detail 526 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR021025 Fanconi Anaemia group E protein, C-terminal
      IPR039685 Fanconi anemia group E protein
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146848, MGI:2147054
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340875 Zhou Z, et al., Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. J Ovarian Res. 2023 Aug 10;16(1):160
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory