Fam76b MGI Mouse Gene Detail - MGI:1920076 - family with sequence similarity 76, member B

Symbol

Fam76b
Name

family with sequence similarity 76, member B
Synonyms

2810485I05Rik

Feature Type

protein coding gene
IDs

MGI:1920076
NCBI Gene: 72826
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:13739012-13766283 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 3.51 cM
Mapping Data

2 experiments

SNPs within 2kb

703 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920076	protein coding gene	Chr9:13738490-13766283 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034346	protein coding gene	Chr9:10747134-10766009 (+)
A/J	MGP_AJ_G0034324	protein coding gene	Chr9:10722235-10741060 (+)
AKR/J	MGP_AKRJ_G0034252	protein coding gene	Chr9:10698668-10718337 (+)
BALB/cJ	MGP_BALBcJ_G0034318	protein coding gene	Chr9:10471471-10490321 (+)
C3H/HeJ	MGP_C3HHeJ_G0034029	protein coding gene	Chr9:10986772-11006579 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034840	protein coding gene	Chr9:11098405-11117225 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031778	protein coding gene	Chr9:10062680-10081914 (+)
CAST/EiJ	MGP_CASTEiJ_G0033356	protein coding gene	Chr9:10822617-10843231 (+)
CBA/J	MGP_CBAJ_G0034002	protein coding gene	Chr9:11606077-11624909 (+)
DBA/2J	MGP_DBA2J_G0034159	protein coding gene	Chr9:10590168-10609471 (+)
FVB/NJ	MGP_FVBNJ_G0034104	protein coding gene	Chr9:10210473-10229298 (+)
LP/J	MGP_LPJ_G0034245	protein coding gene	Chr9:10813152-10831977 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034148	protein coding gene	Chr9:12692862-12711687 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034859	protein coding gene	Chr9:10735830-10754655 (+)
PWK/PhJ	MGP_PWKPhJ_G0033062	protein coding gene	Chr9:10657397-10676764 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032898	protein coding gene	Chr9:10802400-10821668 (+)
WSB/EiJ	MGP_WSBEiJ_G0033472	protein coding gene	Chr9:10555014-10576535 (+)

Human Ortholog

FAM76B, family with sequence similarity 76 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM76B, family with sequence similarity 76 member B
Links

HGNC:28492

NCBI Gene ID: 143684

neXtProt AC: NX_Q5HYJ3

UniProt: Q5HYJ3
Chr Location

11q21; chr11:95768953-95790409 (-) GRCh38

MGI Vertebrate Homology

Fam76b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM76B
Gene Tree

Fam76b

less

Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

3
Gene trapped

4
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have enlarged spleens with altered cell populations and white pulp hypertrophy and show increased microglial cell activation and neuroinflammation with further enhancement of the inflammatory response after brain injury.

less

All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

58
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam76b

ZFIN fam76b

less

All Sequences

62
RefSeq

15
UniProt

3
CCDS

CCDS22819.1

Ensembl

ENSMUSG00000037808 (Evidence)
NCBI Gene

72826

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037808	Ensembl Gene Model \| MGI Sequence Detail	27272	C57BL/6J	± kb
transcript	ENSMUST00000059579	Ensembl \| MGI Sequence Detail	3702	Not Applicable
polypeptide	ENSMUSP00000062642	Ensembl \| MGI Sequence Detail	339	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000029482 protein FAM76B

(term hierarchy)
InterPro Domains

IPR032017 FAM76 protein

less

All nucleic 58

cDNA 58

Microarray probesets 5

less

MGI:2143394

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 10
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:355677 Wang J, et al., FAM76B regulates PI3K/Akt/NF-kappaB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA. Cell Mol Life Sci. 2024 Feb 29;81(1):107

TSS for Fam76b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83825	Chr9:13738514-13738522 (+)	-494 bp
Tssr83826	Chr9:13739004-13739077 (+)	29 bp
Tssr83827	Chr9:13739077-13739080 (+)	67 bp
Tssr83828	Chr9:13739114-13739124 (+)	107 bp
Tssr83829	Chr9:13744346-13744371 (+)	5,347 bp
Tssr83830	Chr9:13746797-13746800 (+)	7,787 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24