Kctd17 MGI Mouse Gene Detail - MGI:1920094 - potassium channel tetramerisation domain containing 17

Symbol

Kctd17
Name

potassium channel tetramerisation domain containing 17
Synonyms

2900008M13Rik

Feature Type

protein coding gene
IDs

MGI:1920094
NCBI Gene: 72844
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:78312764-78323503 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.49 cM
Mapping Data

2 experiments

SNPs within 2kb

228 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920094	protein coding gene	Chr15:78312578-78323503 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022043	protein coding gene	Chr15:78624010-78634371 (+)
A/J	MGP_AJ_G0022004	protein coding gene	Chr15:75926884-75937267 (+)
AKR/J	MGP_AKRJ_G0021979	protein coding gene	Chr15:78017564-78028321 (+)
BALB/cJ	MGP_BALBcJ_G0022010	protein coding gene	Chr15:75900165-75910537 (+)
C3H/HeJ	MGP_C3HHeJ_G0021781	protein coding gene	Chr15:78033039-78043432 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022453	protein coding gene	Chr15:81725509-81735829 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019983	protein coding gene	Chr15:72424660-72435183 (+)
CAST/EiJ	MGP_CASTEiJ_G0021302	protein coding gene	Chr15:78710406-78720769 (+)
CBA/J	MGP_CBAJ_G0021746	protein coding gene	Chr15:84245880-84256231 (+)
DBA/2J	MGP_DBA2J_G0021875	protein coding gene	Chr15:75410234-75422315 (+)
FVB/NJ	MGP_FVBNJ_G0021853	protein coding gene	Chr15:74411168-74422287 (+)
LP/J	MGP_LPJ_G0021943	protein coding gene	Chr15:78829303-78839654 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021873	protein coding gene	Chr15:89440990-89451359 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022467	protein coding gene	Chr15:78059292-78069651 (+)
PWK/PhJ	MGP_PWKPhJ_G0021044	protein coding gene	Chr15:75409371-75419797 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020881	protein coding gene	Chr15:77831640-77841975 (+)
WSB/EiJ	MGP_WSBEiJ_G0021354	protein coding gene	Chr15:78411780-78423741 (+)

Human Ortholog

KCTD17, potassium channel tetramerization domain containing 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCTD17, potassium channel tetramerization domain containing 17
Links

HGNC:25705

NCBI Gene ID: 79734

neXtProt AC: NX_Q8N5Z5

UniProt: Q8N5Z5
Chr Location

22q12.3; chr22:37051739-37063390 (+) GRCh38

MGI Vertebrate Homology

Kctd17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCTD17
Gene Tree

Kctd17

Diseases

1 with human KCTD17 associations

				Human Disease	Mouse Models
				myoclonic dystonia 26 IDs myoclonic dystonia 26 DOID:0090036 OMIM:616398

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Kctd17
Incidental Mutations

CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

77
RefSeq

19
UniProt

8
CCDS

CCDS37132.1, CCDS79384.1, CCDS79385.1

Ensembl

ENSMUSG00000033287 (Evidence)
NCBI Gene

72844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033287	Ensembl Gene Model \| MGI Sequence Detail	10740	C57BL/6J	± kb
transcript	ENSMUST00000089414	Ensembl \| MGI Sequence Detail	1180	Not Applicable
polypeptide	ENSMUSP00000086835	Ensembl \| MGI Sequence Detail	289	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR000210 BTB/POZ domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 7

cDNA 7

Microarray probesets 4

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MGI:2145906, MGI:2146244, MGI:2146317

Summaries

All 49

Developmental Gene Expression 1

Diseases 1

Gene Ontology 2

Phenotypes 26
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kctd17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131952	Chr15:78312647-78312657 (+)	-112 bp
Tssr131953	Chr15:78312825-78312836 (+)	67 bp
Tssr131954	Chr15:78312850-78312871 (+)	97 bp
Tssr131955	Chr15:78314317-78314327 (+)	1,558 bp
Tssr131956	Chr15:78321312-78321345 (+)	8,565 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24