Cox15 MGI Mouse Gene Detail - MGI:1920112 - cytochrome c oxidase assembly protein 15

Symbol

Cox15
Name

cytochrome c oxidase assembly protein 15
Synonyms

2900026G05Rik

Feature Type

protein coding gene
IDs

MGI:1920112
NCBI Gene: 226139
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:43721693-43741439 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.67 cM
Mapping Data

2 experiments

SNPs within 2kb

630 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920112	protein coding gene	Chr19:43721693-43741439 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025156	protein coding gene	Chr19:43150709-43173556 (-)
A/J	MGP_AJ_G0025133	protein coding gene	Chr19:41096910-41117281 (-)
AKR/J	MGP_AKRJ_G0025101	protein coding gene	Chr19:42392804-42414928 (-)
BALB/cJ	MGP_BALBcJ_G0025127	protein coding gene	Chr19:41140891-41164456 (-)
C3H/HeJ	MGP_C3HHeJ_G0024887	protein coding gene	Chr19:42575798-42597938 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025570	protein coding gene	Chr19:44215985-44242189 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022984	protein coding gene	Chr19:40390714-40410282 (-)
CAST/EiJ	MGP_CASTEiJ_G0024352	protein coding gene	Chr19:42263983-42285173 (-)
CBA/J	MGP_CBAJ_G0024867	protein coding gene	Chr19:46409762-46437388 (-)
DBA/2J	MGP_DBA2J_G0024999	protein coding gene	Chr19:40923243-40944052 (-)
FVB/NJ	MGP_FVBNJ_G0024960	protein coding gene	Chr19:40678916-40698807 (-)
LP/J	MGP_LPJ_G0025085	protein coding gene	Chr19:43116703-43139640 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024991	protein coding gene	Chr19:45953943-45978913 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025628	protein coding gene	Chr19:42490270-42511123 (-)
PWK/PhJ	MGP_PWKPhJ_G0024101	protein coding gene	Chr19:40822001-40841993 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023905	protein coding gene	Chr19:41207444-41227133 (-)
WSB/EiJ	MGP_WSBEiJ_G0024422	protein coding gene	Chr19:42626297-42649632 (-)

Human Ortholog

COX15, cytochrome c oxidase assembly homolog COX15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX15, cytochrome c oxidase assembly homolog COX15
Synonyms

CEMCOX2, HAS, MC4DN6
Links

HGNC:2263

NCBI Gene ID: 1355

neXtProt AC: NX_Q7KZN9

UniProt: Q7KZN9
Chr Location

10q24.2; chr10:99694293-99732127 (-) GRCh38

MGI Vertebrate Homology

Cox15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX15
Gene Tree

Cox15

Diseases

3 with human COX15 associations

				Human Disease	Mouse Models
				hypertrophic cardiomyopathy IDs hypertrophic cardiomyopathy DOID:11984 DOID:11986 ICD9CM:425.1 ICD9CM:425.11 KEGG:05410 MESH:D002312 NCI:C34449 ORDO:217569 UMLS_CUI:C0007194
				Leigh disease IDs Leigh disease DOID:3652 ICD10CM:G31.82 MESH:D007888 NCI:C84814 OMIM:256000 ORDO:506 UMLS_CUI:C0023264
				mitochondrial complex IV deficiency nuclear type 6 IDs mitochondrial complex IV deficiency nuclear type 6 DOID:0080358 OMIM:615119 UMLS_CUI:C3554534

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 4 alleles in 5 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality.

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

929
Tissues

143
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox15

ZFIN cox15

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS29836.1

Ensembl

ENSMUSG00000040018 (Evidence)
NCBI Gene

226139

			Length	Strain/Species	Flank
genomic	226139	NCBI Gene Model \| MGI Sequence Detail	19747	C57BL/6J	± kb
transcript	NM_144874	RefSeq \| MGI Sequence Detail	4798	C57BL/6
polypeptide	Q8BJ03	UniProt \| EBI \| MGI Sequence Detail	413	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005771 cytochrome c oxidase assembly protein COX15

(term hierarchy)
EC

1.17.99.9
InterPro Domains

IPR003780 COX15/CtaA family

IPR023754 Heme A synthase, type 2

IPR009003 Peptidase S1, PA clan

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 6

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cox15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159393	Chr19:43741363-43741440 (-)	37 bp
Tssr159392	Chr19:43741330-43741341 (-)	103 bp
Tssr159391	Chr19:43740145-43740147 (-)	1,293 bp
Tssr159390	Chr19:43740101-43740120 (-)	1,328 bp
Tssr159389	Chr19:43728974-43728978 (-)	12,463 bp
Tssr159388	Chr19:43724380-43724383 (-)	17,057 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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