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Setd5 Gene Detail
Summary
  • Symbol
    Setd5
  • Name
    SET domain containing 5
  • Synonyms
    2900045N06Rik, mKIAA1757
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920145
    NCBI Gene: 72895
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113054326-113130393 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.73 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920145
 protein coding gene Chr6:113054326-113130396 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031112
 protein coding gene Chr6:115560393-115641364 (+)
A/J MGP_AJ_G0031081
 protein coding gene Chr6:111149293-111226491 (+)
AKR/J MGP_AKRJ_G0031012
 protein coding gene Chr6:114138547-114214427 (+)
BALB/cJ MGP_BALBcJ_G0031092
 protein coding gene Chr6:111096571-111172355 (+)
C3H/HeJ MGP_C3HHeJ_G0030616
 protein coding gene Chr6:70084780-70161657 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031551
 protein coding gene Chr6:118569760-118649430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028715
 protein coding gene Chr6:108157126-108232151 (+)
CAST/EiJ MGP_CASTEiJ_G0030199
 protein coding gene Chr6:114560191-114642808 (+)
CBA/J MGP_CBAJ_G0030778
 protein coding gene Chr6:123250573-123328800 (+)
DBA/2J MGP_DBA2J_G0030931
 protein coding gene Chr6:110235292-110311417 (+)
FVB/NJ MGP_FVBNJ_G0030885
 protein coding gene Chr6:109226243-109303388 (+)
LP/J MGP_LPJ_G0031011
 protein coding gene Chr6:115616185-115694541 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030919
 protein coding gene Chr6:127532940-127613037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031578
 protein coding gene Chr6:114152858-114229227 (+)
PWK/PhJ MGP_PWKPhJ_G0029915
 protein coding gene Chr6:109179310-109256022 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029743
 protein coding gene Chr6:112970038-113047928 (+)
WSB/EiJ MGP_WSBEiJ_G0030283
 protein coding gene Chr6:114520944-114599695 (+)



Homology
more
  • Human Ortholog
    SETD5, SET domain containing 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SETD5, SET domain containing 5
  • Synonyms
    MRD23, SETD5A
  • Links
    NCBI Gene ID: 55209
    neXtProt AC: NX_Q9C0A6
    UniProt: Q9C0A6

  • Chr Location
    3p25.3; chr3:9397615-9479240 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SETD5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    101 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes embryonic or fetal lethality. Observed phenotypes include embryonic growth retardation, impaired neural tube formation, somitogenesis and cardiac development, abnormal vasculogenesis in embryos, yolk sacs and placentas, hemorrhage and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    111
  • cDNA Data
    133
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72895 NCBI Gene Model | MGI Sequence Detail 76068 C57BL/6J ±  kb
    transcript NM_028385 RefSeq | MGI Sequence Detail 6470 Not Specified  
    polypeptide Q5XJV7 UniProt | EBI | MGI Sequence Detail 1441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 133
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2141772
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory