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Spock3 Gene Detail
Summary
  • Symbol
    Spock3
  • Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
  • Synonyms
    2900045C01Rik, testican 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920152
    NCBI Gene: 72902
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:63404043-63810137 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 31.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920152
 protein coding gene Chr8:63404034-63810137 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033639
 protein coding gene Chr8:62909433-63341317 (+)
A/J MGP_AJ_G0033621
 protein coding gene Chr8:60237112-60638314 (+)
AKR/J MGP_AKRJ_G0033546
 protein coding gene Chr8:61980967-62350947 (+)
BALB/cJ MGP_BALBcJ_G0033617
 protein coding gene Chr8:60514024-60915686 (+)
C3H/HeJ MGP_C3HHeJ_G0033327
 protein coding gene Chr8:62669166-63084111 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034134
 protein coding gene Chr8:65279607-65724830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031082
 protein coding gene Chr8:55374306-55748153 (+)
CAST/EiJ MGP_CASTEiJ_G0032652
 protein coding gene Chr8:62070448-62518336 (+)
CBA/J MGP_CBAJ_G0033305
 protein coding gene Chr8:67637658-68118151 (+)
DBA/2J MGP_DBA2J_G0033459
 protein coding gene Chr8:59993133-60410775 (+)
FVB/NJ MGP_FVBNJ_G0033400
 protein coding gene Chr8:59289514-59690057 (+)
LP/J MGP_LPJ_G0033547
 protein coding gene Chr8:62908119-63327223 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033444
 protein coding gene Chr8:69881506-70455313 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034152
 protein coding gene Chr8:62212861-62633656 (+)
PWK/PhJ MGP_PWKPhJ_G0032361
 protein coding gene Chr8:59364567-59761073 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032197
 protein coding gene Chr8:61197636-61627461 (+)
WSB/EiJ MGP_WSBEiJ_G0032769
 protein coding gene Chr8:62588104-63035028 (+)



Homology
more
  • Human Ortholog
    SPOCK3, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPOCK3, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
  • Synonyms
    HSAJ1454, TES-3, TICN3
  • Links
    NCBI Gene ID: 50859
    neXtProt AC: NX_Q9BQ16
    UniProt: Q9BQ16

  • Chr Location
    4q32.3; chr4:166733384-167234945 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a knock-out allele exhibit no obvious morphological or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    41
  • cDNA Data
    19
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054162 Ensembl Gene Model | MGI Sequence Detail 406095 C57BL/6J ±  kb
transcript ENSMUST00000118003 Ensembl | MGI Sequence Detail 2860 Not Applicable  
polypeptide ENSMUSP00000113683 Ensembl | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 19
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142535
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:308070 Yamamoto A, et al., Structural abnormalities of corpus callosum and cortical axonal tracts accompanied by decreased anxiety-like behavior and lowered sociability in spock3- mutant mice. Dev Neurosci. 2014;36(5):381-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory