Ddx41 MGI Mouse Gene Detail - MGI:1920185

Symbol

Ddx41
Name

DEAD box helicase 41
Synonyms

2900024F02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

Feature Type

protein coding gene
IDs

MGI:1920185
NCBI Gene: 72935
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:55678223-55684471 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM
Mapping Data

2 experiments

SNPs within 2kb

158 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920185	protein coding gene	Chr13:55678223-55684471 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020602	protein coding gene	Chr13:55019824-55026014 (-)
A/J	MGP_AJ_G0020556	protein coding gene	Chr13:52985238-52991419 (-)
AKR/J	MGP_AKRJ_G0020534	protein coding gene	Chr13:54551253-54558678 (-)
BALB/cJ	MGP_BALBcJ_G0020552	protein coding gene	Chr13:53217497-53223679 (-)
C3H/HeJ	MGP_C3HHeJ_G0020351	protein coding gene	Chr13:54362163-54368323 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020986	protein coding gene	Chr13:56676979-56684832 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018568	protein coding gene	Chr13:50923780-50929771 (-)
CAST/EiJ	MGP_CASTEiJ_G0019865	protein coding gene	Chr13:54465025-54471873 (-)
CBA/J	MGP_CBAJ_G0020311	protein coding gene	Chr13:58855255-58861355 (-)
DBA/2J	MGP_DBA2J_G0020434	protein coding gene	Chr13:52536412-52542607 (-)
FVB/NJ	MGP_FVBNJ_G0020413	protein coding gene	Chr13:52007216-52014128 (-)
LP/J	MGP_LPJ_G0020510	protein coding gene	Chr13:55272828-55278843 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020442	protein coding gene	Chr13:58319304-58325501 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021029	protein coding gene	Chr13:54130893-54137108 (-)
PWK/PhJ	MGP_PWKPhJ_G0019621	protein coding gene	Chr13:52563544-52570316 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019448	protein coding gene	Chr13:53060509-53066659 (-)
WSB/EiJ	MGP_WSBEiJ_G0019927	protein coding gene	Chr13:54489792-54497537 (-)

Human Ortholog

DDX41, DEAD-box helicase 41

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX41, DEAD-box helicase 41
Synonyms

ABS, MPLPF
Links

HGNC:18674

NCBI Gene ID: 51428

neXtProt AC: NX_Q9UJV9

UniProt: Q9UJV9
Chr Location

5q35.3; chr5:177511577-177516961 (-) GRCh38

MGI Vertebrate Homology

Ddx41 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX41
Gene Tree

Ddx41

Diseases

1 with human DDX41 associations

				Human Disease	Mouse Models
				myeloproliferative neoplasm IDs myeloproliferative neoplasm DOID:2226 DOID:6002 ICD10CM:D47.1 NCI:C4345 UMLS_CUI:C1292778

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 3 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

7
Genomic Mutations

2 involving Ddx41
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

Constitutive homozygous knockout is embryonic lethal. Conditional homozygous KO in macrophages and DCs (dendritic cells) leads to a depressed immune response to viral infection.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

3
cDNA Data

113
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx41

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All Sequences

56
RefSeq

5
UniProt

5
CCDS

CCDS26549.1

Ensembl

ENSMUSG00000021494 (Evidence)
NCBI Gene

72935

			Length	Strain/Species	Flank
genomic	72935	NCBI Gene Model \| MGI Sequence Detail	6249	C57BL/6J	± kb
transcript	NM_134059	RefSeq \| MGI Sequence Detail	2213	Not Specified
polypeptide	Q91VN6	UniProt \| EBI \| MGI Sequence Detail	622	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000029388 probable ATP-dependent RNA helicase DDX41

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR044113 DDX41, DEAD-box helicase domain

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

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All nucleic 113

cDNA 113

Microarray probesets 3

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MGI:2145174, MGI:2145211

Summaries

All 54

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 20
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:352278 Stepanchick E, et al., DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy. Leukemia. 2024 Aug;38(8):1787-1798

TSS for Ddx41:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122718	Chr13:55684317-55684360 (-)	132 bp
Tssr122717	Chr13:55684208-55684247 (-)	243 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24