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Top1mt Gene Detail
Summary
  • Symbol
    Top1mt
  • Name
    DNA topoisomerase 1, mitochondrial
  • Synonyms
    2900052H09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920210
    NCBI Gene: 72960
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75528884-75550649 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.69 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    725 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920210
 protein coding gene Chr15:75528878-75551184 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021956
 protein coding gene Chr15:75680691-75704185 (-)
A/J MGP_AJ_G0021914
 protein coding gene Chr15:72938926-72960630 (-)
AKR/J MGP_AKRJ_G0021897
 protein coding gene Chr15:74898732-74922489 (-)
BALB/cJ MGP_BALBcJ_G0021923
 protein coding gene Chr15:72951049-72973044 (-)
C3H/HeJ MGP_C3HHeJ_G0021695
 protein coding gene Chr15:74964398-74989007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022363
 protein coding gene Chr15:78516917-78538624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019894
 protein coding gene Chr15:69612906-69635246 (-)
CAST/EiJ MGP_CASTEiJ_G0021214
 protein coding gene Chr15:75742474-75764330 (-)
CBA/J MGP_CBAJ_G0021662
 protein coding gene Chr15:81045342-81067099 (-)
DBA/2J MGP_DBA2J_G0021787
 protein coding gene Chr15:72452567-72474682 (-)
FVB/NJ MGP_FVBNJ_G0021768
 protein coding gene Chr15:71511412-71533556 (-)
LP/J MGP_LPJ_G0021858
 protein coding gene Chr15:75775142-75796899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021792
 protein coding gene Chr15:86318363-86340117 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022383
 protein coding gene Chr15:75149190-75173657 (-)
PWK/PhJ MGP_PWKPhJ_G0020955
 protein coding gene Chr15:72590511-72614144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020794
 protein coding gene Chr15:74879176-74907281 (-)
WSB/EiJ MGP_WSBEiJ_G0021266
 protein coding gene Chr15:75237720-75261112 (-)



Homology
more
  • Human Ortholog
    TOP1MT, DNA topoisomerase I mitochondrial
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOP1MT, DNA topoisomerase I mitochondrial
  • Links
    NCBI Gene ID: 116447
    neXtProt AC: NX_Q969P6
    UniProt: Q969P6

  • Chr Location
    8q24.3; chr8:143304384-143359979 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display increased oxidative stress and lipid peroxidation, enhanced glycolysis, and mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000934 Ensembl Gene Model | MGI Sequence Detail 21766 C57BL/6J ±  kb
    transcript ENSMUST00000000958 Ensembl | MGI Sequence Detail 1903 Not Applicable  
    polypeptide ENSMUSP00000000958 Ensembl | MGI Sequence Detail 593 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016543 DNA topoisomerase I, mitochondrial
      (term hierarchy)
    • EC
      5.6.2.1
    • InterPro Domains
      IPR011010 DNA breaking-rejoining enzyme, catalytic core
      IPR001631 DNA topoisomerase I
      IPR051062 DNA topoisomerase IB
      IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
      IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
      IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
      IPR048045 DNA topoisomerase I, DNA-binding domain
      IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
      IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
      IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1
      IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2
      IPR013499 DNA topoisomerase I, eukaryotic-type
      IPR025834 Topoisomerase I C-terminal domain
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Diseases 1
      Gene Ontology 7
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:270555 Baechler SA, et al., The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis. Nat Commun. 2019 Jan 8;10(1):83
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory