Thap12 MGI Mouse Gene Detail - MGI:1920231

Symbol

Thap12
Name

THAP domain containing 12
Synonyms

2900052B10Rik, Dap4, Prkrir

Feature Type

protein coding gene
IDs

MGI:1920231
NCBI Gene: 72981
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr7:98352310-98367269 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 53.86 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

348 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920231	protein coding gene	Chr7:98352254-98367269 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032542	protein coding gene	Chr7:101449041-101463979 (+)
A/J	MGP_AJ_G0032516	protein coding gene	Chr7:98942377-98957316 (+)
AKR/J	MGP_AKRJ_G0032452	protein coding gene	Chr7:101293259-101308197 (+)
BALB/cJ	MGP_BALBcJ_G0032527	protein coding gene	Chr7:98629057-98643995 (+)
C3H/HeJ	MGP_C3HHeJ_G0032242	protein coding gene	Chr7:101646127-101661075 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033025	protein coding gene	Chr7:105370240-105385198 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030020	protein coding gene	Chr7:101373139-101388371 (+)
CAST/EiJ	MGP_CASTEiJ_G0031569	protein coding gene	Chr7:93173760-93188698 (+)
CBA/J	MGP_CBAJ_G0032209	protein coding gene	Chr7:108958590-108973538 (+)
DBA/2J	MGP_DBA2J_G0032361	protein coding gene	Chr7:97274392-97289343 (+)
FVB/NJ	MGP_FVBNJ_G0032318	protein coding gene	Chr7:97073300-97088238 (+)
LP/J	MGP_LPJ_G0032450	protein coding gene	Chr7:102779947-102794884 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032350	protein coding gene	Chr7:110472634-110488006 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033047	protein coding gene	Chr7:100556918-100571849 (+)
PWK/PhJ	MGP_PWKPhJ_G0031287	protein coding gene	Chr7:90358330-90373273 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031130	protein coding gene	Chr7:87846988-87866381 (+)
WSB/EiJ	MGP_WSBEiJ_G0031686	protein coding gene	Chr7:101225381-101240312 (+)

Human Ortholog

THAP12, THAP domain containing 12

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THAP12, THAP domain containing 12
Synonyms

DAP4, P52rIPK, PRKRIR, THAP0
Links

HGNC:9440

NCBI Gene ID: 5612

neXtProt AC: NX_O43422

UniProt: O43422
Chr Location

11q13.5; chr11:76349898-76381132 (-) GRCh38

MGI Vertebrate Homology

Thap12 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: THAP12
Gene Tree

Thap12

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Thap12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

92
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thap12

ZFIN thap12a, thap12b

less

All Sequences

51
RefSeq

10
UniProt

4
CCDS

CCDS21474.1

Ensembl

ENSMUSG00000030753 (Evidence)
NCBI Gene

72981

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030753	Ensembl Gene Model \| MGI Sequence Detail	14960	C57BL/6J	± kb
transcript	ENSMUST00000033009	Ensembl \| MGI Sequence Detail	3723	Not Applicable
polypeptide	ENSMUSP00000033009	Ensembl \| MGI Sequence Detail	758	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000013243 52 kDa repressor of the inhibitor of the protein kinase

(term hierarchy)
InterPro Domains

IPR025398 Domain of unknown function DUF4371

IPR008906 HAT, C-terminal dimerisation domain

IPR052958 Interferon-induced PKR regulator

IPR012337 Ribonuclease H-like superfamily

IPR006612 THAP-type zinc finger

less

All nucleic 93

cDNA 92

Primer pair 1

Microarray probesets 4

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 17
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:354285 Zhong X, et al., Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2409232121

TSS for Thap12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68032	Chr7:98352298-98352344 (+)	11 bp
Tssr68033	Chr7:98352366-98352377 (+)	62 bp
Tssr68034	Chr7:98352446-98352499 (+)	163 bp
Tssr68035	Chr7:98352505-98352519 (+)	202 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24