About   Help   FAQ
Kremen2 Gene Detail
Summary
  • Symbol
    Kremen2
  • Name
    kringle containing transmembrane protein 2
  • Synonyms
    2900054E04Rik, Krm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920266
    NCBI Gene: 73016
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23960171-23964807 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920266
 protein coding gene Chr17:23960171-23965305 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023269
 protein coding gene Chr17:22658136-22662776 (-)
A/J MGP_AJ_G0023229
 protein coding gene Chr17:22002764-22007404 (-)
AKR/J MGP_AKRJ_G0023199
 protein coding gene Chr17:22083469-22088109 (-)
BALB/cJ MGP_BALBcJ_G0023234
 protein coding gene Chr17:22220213-22224853 (-)
C3H/HeJ MGP_C3HHeJ_G0022994
 protein coding gene Chr17:22442309-22446949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023677
 protein coding gene Chr17:23646445-23651074 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021158
 protein coding gene Chr17:19569336-19573913 (-)
CAST/EiJ MGP_CASTEiJ_G0022500
 protein coding gene Chr17:22274129-22281055 (-)
CBA/J MGP_CBAJ_G0022970
 protein coding gene Chr17:24453881-24461209 (-)
DBA/2J MGP_DBA2J_G0023102
 protein coding gene Chr17:21633480-21638160 (-)
FVB/NJ MGP_FVBNJ_G0023069
 protein coding gene Chr17:21358064-21364048 (-)
LP/J MGP_LPJ_G0023176
 protein coding gene Chr17:22909359-22913966 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023088
 protein coding gene Chr17:24212176-24216816 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023716
 protein coding gene Chr17:22379966-22384606 (-)
PWK/PhJ MGP_PWKPhJ_G0022248
 protein coding gene Chr17:20420013-20424761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022068
 protein coding gene Chr17:20397394-20402024 (-)
WSB/EiJ MGP_WSBEiJ_G0022563
 protein coding gene Chr17:22429927-22434567 (-)



Homology
more
  • Human Ortholog
    KREMEN2, kringle containing transmembrane protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KREMEN2, kringle containing transmembrane protein 2
  • Synonyms
    KRM2
  • Links
    NCBI Gene ID: 79412
    neXtProt AC: NX_Q8NCW0
    UniProt: Q8NCW0

  • Chr Location
    16p13.3; chr16:2964216-2968380 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    6 phenotype references
Mice homozygous for a null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    110
  • cDNA Data
    6
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040680 Ensembl Gene Model | MGI Sequence Detail 4637 C57BL/6J ±  kb
transcript ENSMUST00000046525 Ensembl | MGI Sequence Detail 2123 Not Applicable  
polypeptide ENSMUSP00000046369 Ensembl | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 1
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 39
    Developmental Gene Expression 14
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:324119 Van Otterloo E, et al., AP-2alpha and AP-2beta cooperatively function in the craniofacial surface ectoderm to regulate chromatin and gene expression dynamics during facial development. Elife. 2022 Mar 25;11:e70511
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory