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Tmem192 Gene Detail
Summary
  • Symbol
    Tmem192
  • Name
    transmembrane protein 192
  • Synonyms
    3110005G23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920317
    NCBI Gene: 73067
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:65399837-65421685 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 32.44 cM, cytoband B3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    724 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920317
 protein coding gene Chr8:65399801-65421688 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033645
 protein coding gene Chr8:64973431-64997345 (+)
A/J MGP_AJ_G0033627
 protein coding gene Chr8:62237134-62259256 (+)
AKR/J MGP_AKRJ_G0033552
 protein coding gene Chr8:63999955-64028044 (+)
BALB/cJ MGP_BALBcJ_G0033623
 protein coding gene Chr8:62521659-62544760 (+)
C3H/HeJ MGP_C3HHeJ_G0033333
 protein coding gene Chr8:64741566-64766236 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034140
 protein coding gene Chr8:67399729-67428532 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031087
 protein coding gene Chr8:57504562-57530869 (+)
CAST/EiJ MGP_CASTEiJ_G0032658
 protein coding gene Chr8:64205385-64226799 (+)
CBA/J MGP_CBAJ_G0033311
 protein coding gene Chr8:69900898-69927892 (+)
DBA/2J MGP_DBA2J_G0033465
 protein coding gene Chr8:62049343-62071292 (+)
FVB/NJ MGP_FVBNJ_G0033406
 protein coding gene Chr8:61269339-61290990 (+)
LP/J MGP_LPJ_G0033553
 protein coding gene Chr8:65012096-65034743 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033450
 protein coding gene Chr8:72454666-72475161 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034158
 protein coding gene Chr8:64304419-64327472 (+)
PWK/PhJ MGP_PWKPhJ_G0032367
 protein coding gene Chr8:61383555-61406096 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032203
 protein coding gene Chr8:63285422-63313678 (+)
WSB/EiJ MGP_WSBEiJ_G0032775
 protein coding gene Chr8:64683858-64716304 (+)



Homology
more
  • Human Ortholog
    TMEM192, transmembrane protein 192
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM192, transmembrane protein 192
  • Links
    NCBI Gene ID: 201931
    neXtProt AC: NX_Q8IY95
    UniProt: Q8IY95

  • Chr Location
    4q32.3; chr4:165070608-165208549 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-put allele are viable and overtly normal with no signs of pathology or lysosomal dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    34
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025521 Ensembl Gene Model | MGI Sequence Detail 21849 C57BL/6J ±  kb
transcript ENSMUST00000026595 Ensembl | MGI Sequence Detail 1122 Not Applicable  
polypeptide ENSMUSP00000026595 Ensembl | MGI Sequence Detail 266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:256294 Nguyen TL, et al., Functional characterization of the lysosomal membrane protein TMEM192 in mice. Oncotarget. 2017 Jul 4;8(27):43635-43652
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory