Cenpv MGI Mouse Gene Detail - MGI:1920389

Symbol

Cenpv
Name

centromere protein V
Synonyms

3110013H01Rik, Prr6

Feature Type

protein coding gene
IDs

MGI:1920389
NCBI Gene: 73139
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:62415772-62430087 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.43 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

464 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920389	protein coding gene	Chr11:62415770-62430695 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018455	protein coding gene	Chr11:62570051-62585597 (-)
A/J	MGP_AJ_G0018424	protein coding gene	Chr11:60257752-60272057 (-)
AKR/J	MGP_AKRJ_G0018394	protein coding gene	Chr11:62116020-62130884 (-)
BALB/cJ	MGP_BALBcJ_G0018395	protein coding gene	Chr11:60539503-60554145 (-)
C3H/HeJ	MGP_C3HHeJ_G0018208	protein coding gene	Chr11:62095367-62110508 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018847	protein coding gene	Chr11:64536196-64560098 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016493	protein coding gene	Chr11:57354836-57367251 (-)
CAST/EiJ	MGP_CASTEiJ_G0017765	protein coding gene	Chr11:62231874-62250151 (-)
CBA/J	MGP_CBAJ_G0018182	protein coding gene	Chr11:67339696-67353993 (-)
DBA/2J	MGP_DBA2J_G0018291	protein coding gene	Chr11:59816598-59832002 (-)
FVB/NJ	MGP_FVBNJ_G0018282	protein coding gene	Chr11:59482885-59497748 (-)
LP/J	MGP_LPJ_G0018364	protein coding gene	Chr11:63119349-63134918 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018306	protein coding gene	Chr11:68325591-68339788 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018888	protein coding gene	Chr11:62268332-62282698 (-)
PWK/PhJ	MGP_PWKPhJ_G0017538	protein coding gene	Chr11:60434529-60449266 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017328	protein coding gene	Chr11:62118428-62132332 (-)
WSB/EiJ	MGP_WSBEiJ_G0017817	protein coding gene	Chr11:61883038-61897417 (-)

Human Ortholog

CENPV, centromere protein V

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CENPV, centromere protein V
Synonyms

3110013H01Rik, CENP-V, p30, PRR6
Links

HGNC:29920

NCBI Gene ID: 201161

neXtProt AC: NX_Q7Z7K6

UniProt: Q7Z7K6
Chr Location

17p11.2; chr17:16342534-16353656 (-) GRCh38

Human Ortholog

CENPVL3, centromere protein V like 3
Synonyms

CENPVP3
Links

HGNC:43880

NCBI Gene ID: 347549

UniProt: A0A0U1RRI6
Chr Location

Xp11.22; chrX:51617020-51618912 (-) GRCh38

MGI Vertebrate Homology

Cenpv stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CENPV, CENPVL3
Gene Tree

Cenpv

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Phenotype Summary

6 phenotypes from 3 alleles in 4 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

60
Targeted

4
Genomic Mutations

1 involving Cenpv
Incidental Mutations

CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced female fertility associated with abnormal female meiosis and meitotic spindle integrity.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cenpv

ZFIN cenpv

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All Sequences

46
RefSeq

5
UniProt

2
CCDS

CCDS48818.1

Ensembl

ENSMUSG00000018509 (Evidence)
NCBI Gene

73139

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018509	Ensembl Gene Model \| MGI Sequence Detail	14316	C57BL/6J	± kb
transcript	ENSMUST00000018653	Ensembl \| MGI Sequence Detail	1032	Not Applicable
polypeptide	ENSMUSP00000018653	Ensembl \| MGI Sequence Detail	252	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005339 centromere protein V

(term hierarchy)
InterPro Domains

IPR006913 CENP-V/GFA domain

IPR052355 Centromere protein V-like

IPR011057 Mss4-like superfamily
GlyGen

Q9CXS4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 7

cDNA 7

Microarray probesets 3

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MGI:3034506

Summaries

All 44

Gene Ontology 8

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cenpv:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108428	Chr11:62430107-62430114 (-)	-24 bp
Tssr108427	Chr11:62430083-62430090 (-)	0 bp
Tssr108426	Chr11:62430025-62430079 (-)	35 bp
Tssr108425	Chr11:62430009-62430020 (-)	72 bp
Tssr108424	Chr11:62429917-62429957 (-)	150 bp
Tssr108423	Chr11:62429867-62429898 (-)	204 bp
Tssr108422	Chr11:62429849-62429858 (-)	233 bp
Tssr108421	Chr11:62429730-62429749 (-)	347 bp
Tssr108420	Chr11:62429709-62429724 (-)	370 bp
Tssr108419	Chr11:62428075-62428079 (-)	2,010 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24