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Fezf1 Gene Detail
Summary
  • Symbol
    Fezf1
  • Name
    Fez family zinc finger 1
  • Synonyms
    3110069A13Rik, Fez, Zfp312-like
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920441
    NCBI Gene: 73191
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:23245043-23248361 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 10.55 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920441
 protein coding gene Chr6:23245043-23250942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030487
 protein coding gene Chr6:20782103-20785385 (-)
A/J MGP_AJ_G0030460
 protein coding gene Chr6:19936367-19939681 (-)
AKR/J MGP_AKRJ_G0030387
 protein coding gene Chr6:20586007-20589325 (-)
BALB/cJ MGP_BALBcJ_G0030470
 protein coding gene Chr6:20022648-20025946 (-)
C3H/HeJ MGP_C3HHeJ_G0030183
 protein coding gene Chr6:20528332-20531648 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030924
 protein coding gene Chr6:21438530-21441868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028135
 protein coding gene Chr6:18461040-18463923 (-)
CAST/EiJ MGP_CASTEiJ_G0029585
 protein coding gene Chr6:20452929-20458479 (-)
CBA/J MGP_CBAJ_G0030161
 protein coding gene Chr6:22149781-22153093 (-)
DBA/2J MGP_DBA2J_G0030305
 protein coding gene Chr6:19858419-19862057 (-)
FVB/NJ MGP_FVBNJ_G0030259
 protein coding gene Chr6:19617073-19620373 (-)
LP/J MGP_LPJ_G0030392
 protein coding gene Chr6:20919031-20922309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030295
 protein coding gene Chr6:24026843-24030216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030954
 protein coding gene Chr6:20527563-20530863 (-)
PWK/PhJ MGP_PWKPhJ_G0029299
 protein coding gene Chr6:19478088-19481502 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029135
 protein coding gene Chr6:20235712-20239015 (-)
WSB/EiJ MGP_WSBEiJ_G0029661
 protein coding gene Chr6:20430032-20433330 (-)



Homology
more
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEZF1, FEZ family zinc finger 1
  • Synonyms
    FEZ, HH22, ZNF312B
  • Links
    NCBI Gene ID: 389549
    neXtProt AC: NX_A0PJY2
    UniProt: A0PJY2

  • Chr Location
    7q31.32; chr7:122301303-122310723 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FEZF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display neonatal lethality, impaired olfactory bulb development and impaired olfactory bulb interneuron migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    24
  • cDNA Data
    12
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029697 Ensembl Gene Model | MGI Sequence Detail 3319 C57BL/6J ±  kb
    transcript ENSMUST00000031709 Ensembl | MGI Sequence Detail 2409 Not Applicable  
    polypeptide ENSMUSP00000031709 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 12
      Primer pair 5
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 32
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:337820 Wang Q, et al., Regional and cell-type-specific afferent and efferent projections of the mouse claustrum. Cell Rep. 2023 Feb 11;42(2):112118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory