Itpripl1 MGI Mouse Gene Detail - MGI:1920588 - inositol 1,4,5-triphosphate receptor interacting protein-like 1

Symbol

Itpripl1
Name

inositol 1,4,5-triphosphate receptor interacting protein-like 1
Synonyms

1700041B20Rik

Feature Type

protein coding gene
IDs

MGI:1920588
NCBI Gene: 73338
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:126980692-126985362 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.79 cM
Mapping Data

2 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920588	protein coding gene	Chr2:126980689-126985377 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026450	protein coding gene	Chr2:130395784-130400452 (-)
A/J	MGP_AJ_G0026414	protein coding gene	Chr2:125119339-125124011 (-)
AKR/J	MGP_AKRJ_G0026389	protein coding gene	Chr2:128688289-128692976 (-)
BALB/cJ	MGP_BALBcJ_G0026426	protein coding gene	Chr2:125393096-125397756 (-)
C3H/HeJ	MGP_C3HHeJ_G0026169	protein coding gene	Chr2:129200406-129205054 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026871	protein coding gene	Chr2:134504288-134508966 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024248	protein coding gene	Chr2:119817411-119822061 (-)
CAST/EiJ	MGP_CASTEiJ_G0025630	protein coding gene	Chr2:129413262-129417959 (-)
CBA/J	MGP_CBAJ_G0026149	protein coding gene	Chr2:139471958-139476640 (-)
DBA/2J	MGP_DBA2J_G0026283	protein coding gene	Chr2:124516095-124520756 (-)
FVB/NJ	MGP_FVBNJ_G0026247	protein coding gene	Chr2:123178151-123182822 (-)
LP/J	MGP_LPJ_G0026388	protein coding gene	Chr2:130648854-130653536 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026267	protein coding gene	Chr2:143521232-143525911 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026926	protein coding gene	Chr2:128716198-128720889 (-)
PWK/PhJ	MGP_PWKPhJ_G0025366	protein coding gene	Chr2:124064272-124068924 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025168	protein coding gene	Chr2:127780188-127784846 (-)
WSB/EiJ	MGP_WSBEiJ_G0025704	protein coding gene	Chr2:129606025-129610703 (-)

Human Ortholog

ITPRIPL1, ITPRIP like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITPRIPL1, ITPRIP like 1
Synonyms

D1B, KIAA1754L
Links

HGNC:29371

NCBI Gene ID: 150771

neXtProt AC: NX_Q6GPH6

UniProt: Q6GPH6
Chr Location

2q11.2; chr2:96325317-96330517 (+) GRCh38

MGI Vertebrate Homology

Itpripl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ITPRIPL1
Gene Tree

Itpripl1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Itpripl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show impaired sperm motility, an increase in T cell infiltration within the testis and moderate shrinkage in certain tissue regions of the testis.

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All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

8
UniProt

2
CCDS

CCDS50701.1, CCDS89550.1

Ensembl

ENSMUSG00000074825 (Evidence)
NCBI Gene

73338

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074825	Ensembl Gene Model \| MGI Sequence Detail	4671	C57BL/6J	± kb
transcript	ENSMUST00000110386	Ensembl \| MGI Sequence Detail	1898	Not Applicable
polypeptide	ENSMUSP00000106016	Ensembl \| MGI Sequence Detail	547	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009162 inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

(term hierarchy)
InterPro Domains

IPR026250 Inositol 1,4,5-trisphosphate receptor-interacting protein-like

IPR024810 MAB21L/Cyclic GMP-AMP synthase-like receptor

IPR046906 Mab-21-like, HhH/H2TH-like domain

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All nucleic 16

Genomic 2

cDNA 14

Microarray probesets 2

Summaries

All 29

Gene Ontology 2

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:348064 Deng S, et al., ITPRIPL1 binds CD3epsilon to impede T cell activation and enable tumor immune evasion. Cell. 2024 Apr 25;187(9):2305-2323.e33

TSS for Itpripl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26099	Chr2:126985330-126985399 (-)	-3 bp
Tssr26098	Chr2:126985233-126985250 (-)	120 bp
Tssr26097	Chr2:126983499-126983509 (-)	1,858 bp
Tssr26096	Chr2:126983120-126983166 (-)	2,219 bp
Tssr26095	Chr2:126982884-126982924 (-)	2,458 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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