Arhgef6 MGI Mouse Gene Detail - MGI:1920591 - Rac/Cdc42 guanine nucleotide exchange factor 6

Symbol

Arhgef6
Name

Rac/Cdc42 guanine nucleotide exchange factor 6
Synonyms

1600028C08Rik, 1700038J06Rik, 4930592P22Rik, alpha-PIX

Feature Type

protein coding gene
IDs

MGI:1920591
NCBI Gene: 73341
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

ChrX:56276845-56384089 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 31.26 cM
Mapping Data

2 experiments

SNPs within 2kb

2088 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920591	protein coding gene	ChrX:56276845-56384119 (-)
129S1/SvImJ	ENSMUSG00200037084	protein coding gene	ChrX:38603561-38710849 (-)
A/J	ENSMUSG00195009236	protein coding gene	ChrX:42038162-42145478 (-)
AKR/J	ENSMUSG00220037969	protein coding gene	ChrX:37929328-38036607 (-)
BALB/cJ	ENSMUSG00180032624	protein coding gene	ChrX:38670393-38777743 (-)
C3H/HeJ	ENSMUSG00175040691	protein coding gene	ChrX:42196128-42303456 (-)
C57BL/6NJ	ENSMUSG00215047308	protein coding gene	ChrX:38862315-38969655 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033097	protein coding gene	ChrX:52157390-52264287 (-)
CAST/EiJ	ENSTCUG00005035729	protein coding gene	ChrX:40504432-40610359 (-)
CBA/J	ENSMUSG00210036344	protein coding gene	ChrX:39031714-39139009 (-)
DBA/2J	ENSMUSG00185033755	protein coding gene	ChrX:51350339-51457634 (-)
FVB/NJ	ENSMUSG00205024353	protein coding gene	ChrX:38679123-38786412 (-)
JF1/MsJ	ENSUMUG00000022053	protein coding gene	ChrX:72255783-72361187 (-)
LP/J	ENSMUSG00230028814	protein coding gene	ChrX:57880473-57987759 (-)
NOD/ShiLtJ	ENSMUSG00190032322	protein coding gene	ChrX:38362494-38469770 (-)
NZO/HlLtJ	ENSMUSG00225032345	protein coding gene	ChrX:63121670-63229000 (-)
PWK/PhJ	ENSLUMG00010038579	protein coding gene	ChrX:38205831-38311261 (-)
SPRET/EiJ	ENSMSPG00010022402	protein coding gene	ChrX:40751983-40866840 (-)
WSB/EiJ	ENSIUOG00005046418	protein coding gene	ChrX:39324222-39431587 (-)

Human Ortholog

ARHGEF6, Rac/Cdc42 guanine nucleotide exchange factor 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF6, Rac/Cdc42 guanine nucleotide exchange factor 6
Synonyms

alpha-PIX, alphaPIX, Cool-2, COOL2, MRX46, PIXA
Links

HGNC:685

NCBI Gene ID: 9459

UniProt: Q15052
Chr Location

Xq26.3; chrX:136665547-136781688 (-) GRCh38

MGI Vertebrate Homology

Arhgef6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGEF6
Gene Tree

Arhgef6

Diseases

1 with human ARHGEF6 associations

				Human Disease	Mouse Models
				intellectual disability IDs intellectual disability DOID:1059 NCI:C84392 UMLS_CUI:C0025362

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

1
Targeted

7
Incidental Mutations

CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a truncated allele exhibit decreased mature lymphocyte cell numbers, decreased B and T cell proliferation, and defective humeral response. Mice homozygous for a reporter allele exhibit abnormal dendrite morphology and synaptic plasticity and cognitive defects.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

7
cDNA Data

53
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARHGEF6

ZFIN arhgef6

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All Sequences

78
RefSeq

28
UniProt

5
CCDS

CCDS40984.2

Ensembl

ENSMUSG00000031133 (Evidence)
NCBI Gene

73341

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031133	Ensembl Gene Model \| MGI Sequence Detail	107245	C57BL/6J	± kb
transcript	ENSMUST00000033468	Ensembl \| MGI Sequence Detail	4569	Not Applicable
polypeptide	ENSMUSP00000033468	Ensembl \| MGI Sequence Detail	771	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004259 Rho guanine nucleotide exchange factor 6

(term hierarchy)
PDB

1V61
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR046376 RhoGEF 6/7, PH domain

IPR032409 Rho guanine nucleotide exchange factor 6/7, coiled-coil domain

IPR035788 Rho guanine nucleotide exchange factor 6, SH3 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR003096 Smooth muscle protein/calponin
GlyGen

Q8K4I3 2 sites, 1 O-linked glycan (1 site)

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All nucleic 56

Genomic 1

cDNA 54

Primer pair 1

Microarray probesets 5

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MGI:1923183, MGI:1923947

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arhgef6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163453	ChrX:56384595-56384600 (-)	-509 bp
Tssr163452	ChrX:56384097-56384141 (-)	-30 bp
Tssr163451	ChrX:56383958-56383970 (-)	125 bp
Tssr163450	ChrX:56383873-56383943 (-)	181 bp
Tssr163449	ChrX:56383859-56383872 (-)	223 bp
Tssr163448	ChrX:56372115-56372139 (-)	11,962 bp
Tssr163447	ChrX:56372046-56372072 (-)	12,030 bp
Tssr163446	ChrX:56371953-56372042 (-)	12,091 bp
Tssr163445	ChrX:56371633-56371672 (-)	12,436 bp
Tssr163444	ChrX:56371587-56371609 (-)	12,491 bp
Tssr163443	ChrX:56371508-56371566 (-)	12,552 bp
Tssr163442	ChrX:56350510-56350532 (-)	33,568 bp
Tssr163441	ChrX:56350426-56350470 (-)	33,641 bp
Tssr163440	ChrX:56350394-56350405 (-)	33,689 bp
Tssr163439	ChrX:56350338-56350347 (-)	33,746 bp
Tssr163438	ChrX:56350249-56350258 (-)	33,835 bp
Tssr163437	ChrX:56350197-56350248 (-)	33,866 bp
Tssr163436	ChrX:56326951-56326956 (-)	57,135 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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