Ccsap MGI Mouse Gene Detail - MGI:1920670 - centriole, cilia and spindle associated protein

Symbol

Ccsap
Name

centriole, cilia and spindle associated protein
Synonyms

1700054N08Rik

Feature Type

protein coding gene
IDs

MGI:1920670
NCBI Gene: 73420
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:124567570-124586948 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.22 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

698 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920670	protein coding gene	Chr8:124566712-124586948 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034262	protein coding gene	Chr8:127475073-127497086 (-)
A/J	MGP_AJ_G0034242	protein coding gene	Chr8:122220959-122239823 (-)
AKR/J	MGP_AKRJ_G0034169	protein coding gene	Chr8:125731729-125753362 (-)
BALB/cJ	MGP_BALBcJ_G0034235	protein coding gene	Chr8:122407297-122426893 (-)
C3H/HeJ	MGP_C3HHeJ_G0033946	protein coding gene	Chr8:126370047-126391079 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034755	protein coding gene	Chr8:131754985-131777898 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031697	protein coding gene	Chr8:114998869-115018504 (-)
CAST/EiJ	MGP_CASTEiJ_G0033274	protein coding gene	Chr8:126481132-126503536 (-)
CBA/J	MGP_CBAJ_G0033919	protein coding gene	Chr8:136571149-136592339 (-)
DBA/2J	MGP_DBA2J_G0034075	protein coding gene	Chr8:121374951-121395197 (-)
FVB/NJ	MGP_FVBNJ_G0034019	protein coding gene	Chr8:120536994-120557328 (-)
LP/J	MGP_LPJ_G0034165	protein coding gene	Chr8:127637482-127658715 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034066	protein coding gene	Chr8:138709591-138730764 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034774	protein coding gene	Chr8:125962426-125984421 (-)
PWK/PhJ	MGP_PWKPhJ_G0032975	protein coding gene	Chr8:121129349-121149726 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032815	protein coding gene	Chr8:124609844-124628439 (-)
WSB/EiJ	MGP_WSBEiJ_G0033390	protein coding gene	Chr8:126692700-126713073 (-)

Human Ortholog

CCSAP, centriole, cilia and spindle associated protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCSAP, centriole, cilia and spindle associated protein
Synonyms

C1orf96, CSAP
Links

HGNC:29578

NCBI Gene ID: 126731

neXtProt AC: NX_Q6IQ19

UniProt: Q6IQ19
Chr Location

1q42.13; chr1:229321011-229343294 (-) GRCh38

MGI Vertebrate Homology

Ccsap stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CCSAP
Gene Tree

Ccsap

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

3
Gene trapped

15
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

37
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

3
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ccsapb

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All Sequences

39
RefSeq

5
UniProt

1
CCDS

CCDS22763.1

Ensembl

ENSMUSG00000031971 (Evidence)
NCBI Gene

73420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031971	Ensembl Gene Model \| MGI Sequence Detail	19379	C57BL/6J	± kb
transcript	ENSMUST00000034452	Ensembl \| MGI Sequence Detail	2390	Not Applicable
polypeptide	ENSMUSP00000034452	Ensembl \| MGI Sequence Detail	252	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031246 centriole, cilia and spindle-associated protein

(term hierarchy)
InterPro Domains

IPR029774 Centriole, cilia and spindle-associated protein

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All nucleic 8

cDNA 8

Microarray probesets 6

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MGI:2142638

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ccsap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83382	Chr8:124586697-124586731 (-)	234 bp
Tssr83381	Chr8:124586664-124586694 (-)	269 bp
Tssr83380	Chr8:124586162-124586260 (-)	737 bp
Tssr83379	Chr8:124586137-124586154 (-)	802 bp
Tssr83378	Chr8:124585610-124585630 (-)	1,328 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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