Hspa12a MGI Mouse Gene Detail - MGI:1920692

Symbol

Hspa12a
Name

heat shock protein 12A
Synonyms

1700063D12Rik, Gm19925, Hspa12a, mKIAA0417

Feature Type

protein coding gene
IDs

MGI:1920692
NCBI Gene: 73442
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:58784182-58932086 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 54.51 cM
Mapping Data

3 experiments

SNPs within 2kb

4175 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920692	protein coding gene	Chr19:58784182-58932104 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025282	protein coding gene	Chr19:59284127-59349616 (-)
A/J	MGP_AJ_G0025258	protein coding gene	Chr19:56385475-56452178 (-)
AKR/J	MGP_AKRJ_G0025227	protein coding gene	Chr19:58146603-58212101 (-)
BALB/cJ	MGP_BALBcJ_G0025253	protein coding gene	Chr19:56450239-56515916 (-)
C3H/HeJ	MGP_C3HHeJ_G0025013	protein coding gene	Chr19:58397246-58464949 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025696	protein coding gene	Chr19:60717011-60787680 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023108	protein coding gene	Chr19:55258328-55334801 (-)
CAST/EiJ	MGP_CASTEiJ_G0024478	protein coding gene	Chr19:58471667-58544987 (-)
CBA/J	MGP_CBAJ_G0024993	protein coding gene	Chr19:63682951-63758117 (-)
DBA/2J	MGP_DBA2J_G0025125	protein coding gene	Chr19:56128357-56193995 (-)
FVB/NJ	MGP_FVBNJ_G0025086	protein coding gene	Chr19:55865635-55933454 (-)
LP/J	MGP_LPJ_G0025211	protein coding gene	Chr19:59154273-59224633 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025119	protein coding gene	Chr19:62922230-62989920 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025754	protein coding gene	Chr19:58375359-58443612 (-)
PWK/PhJ	MGP_PWKPhJ_G0024226	protein coding gene	Chr19:56133672-56200588 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024029	protein coding gene	Chr19:57042257-57115312 (-)
WSB/EiJ	MGP_WSBEiJ_G0024548	protein coding gene	Chr19:58496887-58564675 (-)

Human Ortholog

HSPA12A, heat shock protein family A (Hsp70) member 12A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSPA12A, heat shock protein family A (Hsp70) member 12A
Links

HGNC:19022

NCBI Gene ID: 259217

neXtProt AC: NX_O43301

UniProt: O43301
Chr Location

10q25.3; chr10:116671192-116850747 (-) GRCh38

MGI Vertebrate Homology

Hspa12a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSPA12A
Gene Tree

Hspa12a

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

1
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects glucose metabolism, reducing susceptibility to diet-induced obesity. It also reduces diet-induced damage to the liver through suppression of macrophage recruitment, increases LPS-induced liver damage and increases susceptibility to ischemic brain injury.

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

29
cDNA Data

82
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

79
RefSeq

16
UniProt

5
CCDS

CCDS38032.1

Ensembl

ENSMUSG00000025092 (Evidence)
NCBI Gene

73442

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025092	Ensembl Gene Model \| MGI Sequence Detail	147905	C57BL/6J	± kb
transcript	ENSMUST00000066285	Ensembl \| MGI Sequence Detail	5734	Not Applicable
polypeptide	ENSMUSP00000066860	Ensembl \| MGI Sequence Detail	675	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008802 heat shock 70 kDa protein 12A

(term hierarchy)
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR026685 Heat shock 70kDa protein 12A, nucleotide-binding domain
GlyGen

Q8K0U4 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 85

cDNA 85

Microarray probesets 9

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MGI:2147603, MGI:2147692, MGI:2147750, MGI:5012110

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 17
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:354337 Yu W, et al., HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury. JCI Insight. 2024 Apr 8;9(7)

TSS for Hspa12a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159991	Chr19:58932026-58932080 (-)	33 bp
Tssr159990	Chr19:58932008-58932025 (-)	69 bp
Tssr159989	Chr19:58931989-58932004 (-)	89 bp
Tssr159988	Chr19:58849445-58849454 (-)	82,636 bp
Tssr159987	Chr19:58849407-58849429 (-)	82,668 bp
Tssr159986	Chr19:58849380-58849402 (-)	82,695 bp
Tssr159985	Chr19:58810968-58810990 (-)	121,107 bp
Tssr159984	Chr19:58810953-58810964 (-)	121,127 bp
Tssr159983	Chr19:58810883-58810901 (-)	121,194 bp
Tssr159982	Chr19:58810870-58810879 (-)	121,211 bp
Tssr159981	Chr19:58795960-58795965 (-)	136,123 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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