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Izumo1 Gene Detail
Summary
  • Symbol
    Izumo1
  • Name
    izumo sperm-egg fusion 1
  • Synonyms
    1700058F15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920706
    NCBI Gene: 73456
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45270251-45276653 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.39 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920706
 protein coding gene Chr7:45270251-45278247 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032234
 protein coding gene Chr7:45921552-45928561 (+)
A/J MGP_AJ_G0032213
 protein coding gene Chr7:45015960-45022959 (+)
AKR/J MGP_AKRJ_G0032149
 protein coding gene Chr7:46264921-46271926 (+)
BALB/cJ MGP_BALBcJ_G0032225
 protein coding gene Chr7:45009677-45016637 (+)
C3H/HeJ MGP_C3HHeJ_G0031940
 protein coding gene Chr7:46755709-46763136 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032717
 protein coding gene Chr7:48175999-48182991 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029731
 protein coding gene Chr7:47561422-47568180 (+)
CAST/EiJ MGP_CASTEiJ_G0031269
 protein coding gene Chr7:38193779-38202696 (+)
CBA/J MGP_CBAJ_G0031905
 protein coding gene Chr7:49779066-49785908 (+)
DBA/2J MGP_DBA2J_G0032063
 protein coding gene Chr7:44693868-44701048 (+)
FVB/NJ MGP_FVBNJ_G0032014
 protein coding gene Chr7:44466580-44473848 (+)
LP/J MGP_LPJ_G0032141
 protein coding gene Chr7:46625822-46636195 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032051
 protein coding gene Chr7:48464052-48471336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032733
 protein coding gene Chr7:45474618-45484076 (+)
PWK/PhJ MGP_PWKPhJ_G0030991
 protein coding gene Chr7:38061626-38069046 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030829
 protein coding gene Chr7:33502677-33509472 (+)
WSB/EiJ MGP_WSBEiJ_G0031386
 protein coding gene Chr7:45978995-45987379 (+)



Homology
more
  • Human Ortholog
    IZUMO1, izumo sperm-oocyte fusion 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IZUMO1, izumo sperm-oocyte fusion 1
  • Synonyms
    IZUMO, OBF
  • Links
    NCBI Gene ID: 284359
    neXtProt AC: NX_Q8IYV9
    UniProt: Q8IYV9

  • Chr Location
    19q13.33; chr19:48740852-48746909 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice are infertile due to inability of sperm to fuse with the egg.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73456 NCBI Gene Model | MGI Sequence Detail 6403 C57BL/6J ±  kb
    transcript NM_001018013 RefSeq | MGI Sequence Detail 1460 C57BL/6  
    polypeptide Q9D9J7 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333062 Brukman NG, et al., A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion. J Cell Biol. 2023 Feb 6;222(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory