Glipr1 MGI Mouse Gene Detail - MGI:1920940 - GLI pathogenesis related 1

Symbol

Glipr1
Name

GLI pathogenesis related 1
Synonyms

2410114O14Rik, mRTVP-1, RTVP-1, RTVP1

Feature Type

protein coding gene
IDs

MGI:1920940
NCBI Gene: 73690
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr10:111821353-111838536 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 59.98 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

684 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920940	protein coding gene	Chr10:111821353-111838539 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017724	protein coding gene	Chr10:114453372-114472265 (-)
A/J	MGP_AJ_G0017701	protein coding gene	Chr10:110080461-110097596 (-)
AKR/J	MGP_AKRJ_G0017663	protein coding gene	Chr10:113301881-113318967 (-)
BALB/cJ	MGP_BALBcJ_G0017665	protein coding gene	Chr10:110485337-110502292 (-)
C3H/HeJ	MGP_C3HHeJ_G0017490	protein coding gene	Chr10:113449228-113467891 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018122	protein coding gene	Chr10:118385500-118405348 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015801	protein coding gene	Chr10:104938060-104955815 (-)
CAST/EiJ	MGP_CASTEiJ_G0017051	protein coding gene	Chr10:113636970-113655811 (-)
CBA/J	MGP_CBAJ_G0017459	protein coding gene	Chr10:123038298-123056769 (-)
DBA/2J	MGP_DBA2J_G0017564	protein coding gene	Chr10:109222307-109239709 (-)
FVB/NJ	MGP_FVBNJ_G0017558	protein coding gene	Chr10:108206501-108224395 (-)
LP/J	MGP_LPJ_G0017638	protein coding gene	Chr10:115087711-115106511 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017587	protein coding gene	Chr10:125646638-125665450 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018160	protein coding gene	Chr10:113319791-113336826 (-)
PWK/PhJ	MGP_PWKPhJ_G0016833	protein coding gene	Chr10:109303395-109321380 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016623	protein coding gene	Chr10:112095125-112114825 (-)
WSB/EiJ	MGP_WSBEiJ_G0017111	protein coding gene	Chr10:113461159-113478175 (-)

Human Ortholog

GLIPR1, GLI pathogenesis related 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLIPR1, GLI pathogenesis related 1
Synonyms

CRISP7, GLIPR, RTVP1
Links

HGNC:17001

NCBI Gene ID: 11010

neXtProt AC: NX_P48060

UniProt: P48060
Chr Location

12q21.2; chr12:75480753-75503863 (+) GRCh38

MGI Vertebrate Homology

Glipr1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GLIPR1
Gene Tree

Glipr1

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Glipr1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted inactivation of this gene renders mice more vulnerable to spontaneous tumorigenesis, leading to the formation of a wide spectrum of tumors and significantly shorter tumor-free survival times.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

30
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

6
UniProt

3
CCDS

CCDS24169.1

Ensembl

ENSMUSG00000056888 (Evidence)
NCBI Gene

73690

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056888	Ensembl Gene Model \| MGI Sequence Detail	17184	C57BL/6J	± kb
transcript	ENSMUST00000162508	Ensembl \| MGI Sequence Detail	1183	Not Applicable
polypeptide	ENSMUSP00000123990	Ensembl \| MGI Sequence Detail	255	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008030 glioma pathogenesis-related protein 1

(term hierarchy)
InterPro Domains

IPR018244 Allergen V5/Tpx-1-related, conserved site

IPR014044 CAP domain

IPR035940 CAP superfamily

IPR001283 Cysteine-rich secretory protein-related

IPR002413 Venom allergen 5-like

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All nucleic 32

cDNA 32

Microarray probesets 2

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Glipr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99286	Chr10:111838628-111838665 (-)	-111 bp
Tssr99285	Chr10:111838517-111838541 (-)	7 bp
Tssr99284	Chr10:111833109-111833184 (-)	5,389 bp
Tssr99283	Chr10:111833071-111833107 (-)	5,447 bp
Tssr99282	Chr10:111833053-111833061 (-)	5,479 bp
Tssr99281	Chr10:111833034-111833045 (-)	5,496 bp
Tssr99280	Chr10:111833024-111833031 (-)	5,508 bp
Tssr99279	Chr10:111833004-111833017 (-)	5,525 bp
Tssr99278	Chr10:111832537-111832548 (-)	5,993 bp
Tssr99277	Chr10:111831813-111831831 (-)	6,714 bp
Tssr99276	Chr10:111831796-111831807 (-)	6,734 bp
Tssr99275	Chr10:111831772-111831783 (-)	6,758 bp
Tssr99274	Chr10:111831459-111831467 (-)	7,073 bp
Tssr99273	Chr10:111829491-111829510 (-)	9,035 bp
Tssr99272	Chr10:111829432-111829444 (-)	9,098 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24