Ppp2r1b MGI Mouse Gene Detail - MGI:1920949 - protein phosphatase 2, regulatory subunit A, beta

Symbol

Ppp2r1b
Name

protein phosphatase 2, regulatory subunit A, beta
Synonyms

2410091N08Rik

Feature Type

protein coding gene
IDs

MGI:1920949
NCBI Gene: 73699
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:50767946-50810625 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 27.75 cM
Mapping Data

2 experiments

SNPs within 2kb

929 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920949	protein coding gene	Chr9:50756601-50810625 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034793	protein coding gene	Chr9:49751603-49800083 (+)
A/J	MGP_AJ_G0034774	protein coding gene	Chr9:48233312-48282304 (+)
AKR/J	MGP_AKRJ_G0034702	protein coding gene	Chr9:49245465-49295446 (+)
BALB/cJ	MGP_BALBcJ_G0034766	protein coding gene	Chr9:47974793-48023917 (+)
C3H/HeJ	MGP_C3HHeJ_G0034476	protein coding gene	Chr9:49737649-49789365 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035286	protein coding gene	Chr9:51134720-51186459 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032199	protein coding gene	Chr9:47696837-47746660 (+)
CAST/EiJ	MGP_CASTEiJ_G0033798	protein coding gene	Chr9:49683056-49732813 (+)
CBA/J	MGP_CBAJ_G0034448	protein coding gene	Chr9:52962521-53011831 (+)
DBA/2J	MGP_DBA2J_G0034607	protein coding gene	Chr9:48097879-48146304 (+)
FVB/NJ	MGP_FVBNJ_G0034548	protein coding gene	Chr9:47313122-47362284 (+)
LP/J	MGP_LPJ_G0034688	protein coding gene	Chr9:50112743-50164220 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034591	protein coding gene	Chr9:54545190-54595446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035307	protein coding gene	Chr9:49232378-49282480 (+)
PWK/PhJ	MGP_PWKPhJ_G0033503	protein coding gene	Chr9:48070985-48120421 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033338	protein coding gene	Chr9:49532363-49583550 (+)
WSB/EiJ	MGP_WSBEiJ_G0033911	protein coding gene	Chr9:49230214-49281723 (+)

Human Ortholog

PPP2R1B, protein phosphatase 2 scaffold subunit Abeta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP2R1B, protein phosphatase 2 scaffold subunit Abeta
Synonyms

PP2A-Abeta, PR65B
Links

HGNC:9303

NCBI Gene ID: 5519

neXtProt AC: NX_P30154

UniProt: P30154
Chr Location

11q23.1; chr11:111688000-111766389 (-) GRCh38

MGI Vertebrate Homology

Ppp2r1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP2R1B
Gene Tree

Ppp2r1b

Diseases

1 with human PPP2R1B associations

				Human Disease	Mouse Models
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

35
cDNA Data

13
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp2r1b

ZFIN ppp2r1ba, ppp2r1bb

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All Sequences

81
RefSeq

14
UniProt

10
CCDS

CCDS40625.1, CCDS40626.1, CCDS72232.1

Ensembl

ENSMUSG00000032058 (Evidence)
NCBI Gene

73699

			Length	Strain/Species	Flank
genomic	73699	NCBI Gene Model \| MGI Sequence Detail	42680	C57BL/6J	± kb
transcript	NM_001034085	RefSeq \| MGI Sequence Detail	3647	C57BL/6
polypeptide	Q7TNP2	UniProt \| EBI \| MGI Sequence Detail	601	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000013135 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR000357 HEAT repeat

IPR021133 HEAT, type 2

IPR051023 Protein Phosphatase 2A Regulatory Subunit A

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All nucleic 15

cDNA 13

Primer pair 2

Microarray probesets 6

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MGI:2143121

Summaries

All 39

Developmental Gene Expression 8

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp2r1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85076	Chr9:50768238-50768287 (+)	317 bp
Tssr85077	Chr9:50796788-50796798 (+)	28,847 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24