Megf11 MGI Mouse Gene Detail - MGI:1920951 - multiple EGF-like-domains 11

Symbol

Megf11
Name

multiple EGF-like-domains 11
Synonyms

2410080H04Rik

Feature Type

protein coding gene
IDs

MGI:1920951
NCBI Gene: 214058
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr9:64292908-64616487 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 34.67 cM
Mapping Data

1 experiment

SNPs within 2kb

7881 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920951	protein coding gene	Chr9:64291556-64618584 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034942	protein coding gene	Chr9:64058742-64391441 (+)
A/J	MGP_AJ_G0034922	protein coding gene	Chr9:61911139-62232963 (+)
AKR/J	MGP_AKRJ_G0034852	protein coding gene	Chr9:63354303-63684858 (+)
BALB/cJ	MGP_BALBcJ_G0034915	protein coding gene	Chr9:61640085-61958640 (+)
C3H/HeJ	MGP_C3HHeJ_G0034625	protein coding gene	Chr9:63883687-64211636 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035434	protein coding gene	Chr9:65808216-66151606 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032345	protein coding gene	Chr9:61556138-61873104 (+)
CAST/EiJ	MGP_CASTEiJ_G0033946	protein coding gene	Chr9:64049486-64382947 (+)
CBA/J	MGP_CBAJ_G0034596	protein coding gene	Chr9:68081038-68433409 (+)
DBA/2J	MGP_DBA2J_G0034755	protein coding gene	Chr9:61695619-62015777 (+)
FVB/NJ	MGP_FVBNJ_G0034697	protein coding gene	Chr9:60994132-61320413 (+)
LP/J	MGP_LPJ_G0034838	protein coding gene	Chr9:64344170-64674287 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034739	protein coding gene	Chr9:69359314-69712568 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035456	protein coding gene	Chr9:63471201-63798622 (+)
PWK/PhJ	MGP_PWKPhJ_G0033650	protein coding gene	Chr9:61849146-62170038 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033484	protein coding gene	Chr9:63740687-64063885 (+)
WSB/EiJ	MGP_WSBEiJ_G0034059	protein coding gene	Chr9:63361681-63691908 (+)

Human Ortholog

MEGF11, multiple EGF like domains 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEGF11, multiple EGF like domains 11
Links

HGNC:29635

NCBI Gene ID: 84465

neXtProt AC: NX_A6BM72

UniProt: A6BM72
Chr Location

15q22.31; chr15:65895079-66253756 (-) GRCh38

MGI Vertebrate Homology

Megf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MEGF11
Gene Tree

Megf11

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Gene trapped

16
Targeted

2
Genomic Mutations

1 involving Megf11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

Mice homozygous for a targeted allele exhibit abnormal spacing of horizontal cells.

less

All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

8
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase megf11

less

All Sequences

181
RefSeq

124
UniProt

4
CCDS

CCDS23281.1, CCDS52833.1

Ensembl

ENSMUSG00000036466 (Evidence)
NCBI Gene

214058

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036466	Ensembl Gene Model \| MGI Sequence Detail	323580	C57BL/6J	± kb
transcript	ENSMUST00000164113	Ensembl \| MGI Sequence Detail	6018	Not Applicable
polypeptide	ENSMUSP00000128672	Ensembl \| MGI Sequence Detail	1095	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000030849 multiple epidermal growth factor-like domains protein 11

(term hierarchy)
InterPro Domains

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR011489 EMI domain

IPR002049 Laminin-type EGF domain

IPR042635 MEGF10/SREC1/2-like

IPR052108 Multiple EGF-like domains/Integrin beta-like
GlyGen

Q80T91 2 sites

less

All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:290493 Peng YR, et al., Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. Neuron. 2020 Feb 5;105(3):464-474.e6

TSS for Megf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85614	Chr9:64292928-64292939 (+)	26 bp
Tssr85615	Chr9:64292957-64292980 (+)	61 bp
Tssr85616	Chr9:64303909-64303914 (+)	11,004 bp
Tssr85617	Chr9:64305003-64305008 (+)	12,098 bp
Tssr85618	Chr9:64393251-64393255 (+)	100,345 bp
Tssr85619	Chr9:64452209-64452212 (+)	159,303 bp
Tssr85620	Chr9:64454177-64454183 (+)	161,272 bp
Tssr2908	Chr9:64612127-64612128 (+)	319,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24