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Mark4 Gene Detail
Summary
  • Symbol
    Mark4
  • Name
    MAP/microtubule affinity regulating kinase 4
  • Synonyms
    2410090P21Rik, Markl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920955
    NCBI Gene: 232944
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19158700-19192746 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1090 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920955
 protein coding gene Chr7:19158700-19193255 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031778
 protein coding gene Chr7:17424537-17462219 (-)
A/J MGP_AJ_G0031754
 protein coding gene Chr7:17071824-17103975 (-)
AKR/J MGP_AKRJ_G0031680
 protein coding gene Chr7:17544179-17576895 (-)
BALB/cJ MGP_BALBcJ_G0031759
 protein coding gene Chr7:17272063-17307975 (-)
C3H/HeJ MGP_C3HHeJ_G0031481
 protein coding gene Chr7:17803832-17839347 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032225
 protein coding gene Chr7:18299836-18338891 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029291
 protein coding gene Chr7:18716823-18752553 (-)
CAST/EiJ MGP_CASTEiJ_G0030825
 protein coding gene Chr7:14225778-14264611 (-)
CBA/J MGP_CBAJ_G0031443
 protein coding gene Chr7:18958169-18990959 (-)
DBA/2J MGP_DBA2J_G0031598
 protein coding gene Chr7:17013234-17046742 (-)
FVB/NJ MGP_FVBNJ_G0031550
 protein coding gene Chr7:16874947-16909818 (-)
LP/J MGP_LPJ_G0031681
 protein coding gene Chr7:17747797-17789664 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031586
 protein coding gene Chr7:18817074-18851324 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032253
 protein coding gene Chr7:17140846-17176061 (-)
PWK/PhJ MGP_PWKPhJ_G0030548
 protein coding gene Chr7:14107983-14140477 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030375
 protein coding gene Chr7:11853645-11889999 (-)
WSB/EiJ MGP_WSBEiJ_G0030924
 protein coding gene Chr7:17367883-17401978 (-)



Homology
more
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARK4, microtubule affinity regulating kinase 4
  • Synonyms
    MARK4L, MARK4S, MARKL1, MARKL1L, PAR-1D
  • Links
    NCBI Gene ID: 57787
    neXtProt AC: NX_Q96L34
    UniProt: Q96L34

  • Chr Location
    19q13.32; chr19:45079288-45305284 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit insulin hypersensitivity and resistance to diet-induced obersity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030397 Ensembl Gene Model | MGI Sequence Detail 34047 C57BL/6J ±  kb
    transcript ENSMUST00000085715 Ensembl | MGI Sequence Detail 3886 Not Applicable  
    polypeptide ENSMUSP00000082862 Ensembl | MGI Sequence Detail 752 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010189 MAP/microtubule affinity-regulating kinase 4
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR028375 KA1 domain/Ssp2, C-terminal
      IPR001772 Kinase associated domain 1 (KA1)
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
      IPR049508 Serine/threonine-protein kinase MARK 1-4, catalytic domain
      IPR015940 Ubiquitin-associated domain
    • GlyGen
      Q8CIP4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2142337
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350520 Sultanakhmetov G, et al., Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy. Brain Commun. 2024;6(3):fcae136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory