Dmkn MGI Mouse Gene Detail - MGI:1920962

Symbol

Dmkn
Name

dermokine
Synonyms

1110014F24Rik, cI-36, dermokine, Dmkn, sk30, sk89

Feature Type

protein coding gene
IDs

MGI:1920962
NCBI Gene: 73712
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:30463181-30480488 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 19.24 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

527 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920962	protein coding gene	Chr7:30463181-30480491 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032044	protein coding gene	Chr7:29776327-29793395 (+)
A/J	MGP_AJ_G0032021	protein coding gene	Chr7:28966452-28984442 (+)
AKR/J	MGP_AKRJ_G0031954	protein coding gene	Chr7:29710742-29727650 (+)
BALB/cJ	MGP_BALBcJ_G0032028	protein coding gene	Chr7:29157368-29175364 (+)
C3H/HeJ	MGP_C3HHeJ_G0031747	protein coding gene	Chr7:30169668-30187512 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032494	protein coding gene	Chr7:30757301-30774273 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029544	protein coding gene	Chr7:29986149-30003641 (+)
CAST/EiJ	MGP_CASTEiJ_G0031081	protein coding gene	Chr7:23419774-23439544 (+)
CBA/J	MGP_CBAJ_G0031713	protein coding gene	Chr7:32205202-32225331 (+)
DBA/2J	MGP_DBA2J_G0031865	protein coding gene	Chr7:28693613-28710202 (+)
FVB/NJ	MGP_FVBNJ_G0031822	protein coding gene	Chr7:28831766-28849135 (+)
LP/J	MGP_LPJ_G0031946	protein coding gene	Chr7:30094782-30114077 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031858	protein coding gene	Chr7:31445753-31464300 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032522	protein coding gene	Chr7:29216343-29234552 (+)
PWK/PhJ	MGP_PWKPhJ_G0030805	protein coding gene	Chr7:23740801-23757995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030640	protein coding gene	Chr7:20225842-20243807 (+)
WSB/EiJ	MGP_WSBEiJ_G0031191	protein coding gene	Chr7:29621818-29641391 (+)

Human Ortholog

DMKN, dermokine

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMKN, dermokine
Synonyms

UNQ729, ZD52F10
Links

HGNC:25063

NCBI Gene ID: 93099

neXtProt AC: NX_Q6E0U4

UniProt: Q6E0U4
Chr Location

19q13.12; chr19:35497220-35513658 (-) GRCh38

MGI Vertebrate Homology

Dmkn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DMKN
Gene Tree

Dmkn

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice null for the beta and gamma isoforms are viable and fertile with no overt phenotype except a transient scaly skin during the first week of life.

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All GO Annotations

5
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

6
cDNA Data

80
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

55
RefSeq

10
UniProt

5
CCDS

CCDS39892.1, CCDS39893.1, CCDS52183.1, CCDS52184.1

Ensembl

ENSMUSG00000060962 (Evidence)
NCBI Gene

73712

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060962	Ensembl Gene Model \| MGI Sequence Detail	17308	C57BL/6J	± kb
transcript	ENSMUST00000165887	Ensembl \| MGI Sequence Detail	2063	Not Applicable
polypeptide	ENSMUSP00000129031	Ensembl \| MGI Sequence Detail	524	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006539 dermokine

(term hierarchy)
InterPro Domains

IPR033541 Dermokine

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All nucleic 80

cDNA 80

Microarray probesets 3

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MGI:1930794

Summaries

All 33

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 7
Earliest

J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
Latest

J:297240 Utsunomiya A, et al., Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. J Invest Dermatol. 2020 Apr;140(4):838-849.e9

TSS for Dmkn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65809	Chr7:30463175-30463190 (+)	2 bp
Tssr65810	Chr7:30464214-30464227 (+)	1,040 bp
Tssr65811	Chr7:30464831-30464875 (+)	1,672 bp
Tssr65812	Chr7:30465998-30466001 (+)	2,819 bp
Tssr65813	Chr7:30475819-30475835 (+)	12,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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