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Hoatz Gene Detail
Summary
  • Symbol
    Hoatz
  • Name
    HOATZ cilia and flagella associated protein
  • Synonyms
    4833427G06Rik, Hoatzin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921013
    NCBI Gene: 235345
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50992415-51013378 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.81 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    547 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921013
 protein coding gene Chr9:50992415-51017183 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034796
 protein coding gene Chr9:49994601-50017467 (-)
A/J MGP_AJ_G0034777
 protein coding gene Chr9:48475564-48497582 (-)
AKR/J MGP_AKRJ_G0034705
 protein coding gene Chr9:49487070-49507301 (-)
BALB/cJ MGP_BALBcJ_G0034769
 protein coding gene Chr9:48221330-48247633 (-)
C3H/HeJ MGP_C3HHeJ_G0034479
 protein coding gene Chr9:49980231-50002592 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035289
 protein coding gene Chr9:51392580-51415901 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032202
 protein coding gene Chr9:47935561-47955968 (-)
CAST/EiJ MGP_CASTEiJ_G0033801
 protein coding gene Chr9:49920071-49942803 (-)
CBA/J MGP_CBAJ_G0034451
 protein coding gene Chr9:53209906-53235097 (-)
DBA/2J MGP_DBA2J_G0034610
 protein coding gene Chr9:48334401-48355047 (-)
FVB/NJ MGP_FVBNJ_G0034551
 protein coding gene Chr9:47548416-47571066 (-)
LP/J MGP_LPJ_G0034691
 protein coding gene Chr9:50360631-50384874 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034594
 protein coding gene Chr9:54793845-54814148 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035310
 protein coding gene Chr9:49475764-49496888 (-)
PWK/PhJ MGP_PWKPhJ_G0033506
 protein coding gene Chr9:48308206-48329359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033341
 protein coding gene Chr9:49773049-49794902 (-)
WSB/EiJ MGP_WSBEiJ_G0033914
 protein coding gene Chr9:49483702-49506428 (-)



Homology
more
  • Human Ortholog
    HOATZ, HOATZ cilia and flagella associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOATZ, HOATZ cilia and flagella associated protein
  • Synonyms
    C11orf88
  • Links
    NCBI Gene ID: 399949
    neXtProt AC: NX_Q6PI97
    UniProt: Q6PI97

  • Chr Location
    11q23.1; chr11:111514778-111537043 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop hydrocephalus, male infertility, oligo-astheno-terato-zoospermia, and disorganized axonemes in epdendymal cilia and sperm flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032057 Ensembl Gene Model | MGI Sequence Detail 20964 C57BL/6J ±  kb
    transcript ENSMUST00000170947 Ensembl | MGI Sequence Detail 973 Not Applicable  
    polypeptide ENSMUSP00000126725 Ensembl | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000059868 cilia- and flagella-associated protein HOATZ
      (term hierarchy)
    • InterPro Domains
      IPR040681 Cilia- and flagella-associated protein HOATZ-like
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6416440
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:287082 Narita K, et al., Discovery of a Vertebrate-Specific Factor that Processes Flagellar Glycolytic Enolase during Motile Ciliogenesis. iScience. 2020 Mar 19;23(4):100992
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory