Neurl4 MGI Mouse Gene Detail - MGI:1921092 - neuralized E3 ubiquitin protein ligase 4

Symbol

Neurl4
Name

neuralized E3 ubiquitin protein ligase 4
Synonyms

0610025P10Rik

Feature Type

protein coding gene
IDs

MGI:1921092
NCBI Gene: 216860
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:69792545-69804648 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.92 cM
Mapping Data

2 experiments

SNPs within 2kb

60 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921092	protein coding gene	Chr11:69791898-69804648 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018567	protein coding gene	Chr11:70388004-70400757 (+)
A/J	MGP_AJ_G0018535	protein coding gene	Chr11:67722750-67735492 (+)
AKR/J	MGP_AKRJ_G0018504	protein coding gene	Chr11:69745101-69757849 (+)
BALB/cJ	MGP_BALBcJ_G0018507	protein coding gene	Chr11:68054093-68066841 (+)
C3H/HeJ	MGP_C3HHeJ_G0018320	protein coding gene	Chr11:69781661-69794409 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018958	protein coding gene	Chr11:72513410-72526364 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016603	protein coding gene	Chr11:64649622-64662130 (+)
CAST/EiJ	MGP_CASTEiJ_G0017875	protein coding gene	Chr11:70021893-70034649 (+)
CBA/J	MGP_CBAJ_G0018293	protein coding gene	Chr11:75761917-75775998 (+)
DBA/2J	MGP_DBA2J_G0018402	protein coding gene	Chr11:67308651-67321410 (+)
FVB/NJ	MGP_FVBNJ_G0018392	protein coding gene	Chr11:66948686-66962685 (+)
LP/J	MGP_LPJ_G0018472	protein coding gene	Chr11:70968607-70983520 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018415	protein coding gene	Chr11:76357502-76370250 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019000	protein coding gene	Chr11:70015550-70028295 (+)
PWK/PhJ	MGP_PWKPhJ_G0017649	protein coding gene	Chr11:67959193-67972020 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017439	protein coding gene	Chr11:69824410-69837697 (+)
WSB/EiJ	MGP_WSBEiJ_G0017929	protein coding gene	Chr11:69678074-69690823 (+)

Human Ortholog

NEURL4, neuralized E3 ubiquitin protein ligase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEURL4, neuralized E3 ubiquitin protein ligase 4
Links

HGNC:34410

NCBI Gene ID: 84461

neXtProt AC: NX_Q96JN8

UniProt: Q96JN8
Chr Location

17p13.1; chr17:7315628-7329393 (-) GRCh38

MGI Vertebrate Homology

Neurl4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NEURL4
Gene Tree

Neurl4

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Targeted

3
Genomic Mutations

2 involving Neurl4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

127
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase neurl4

ZFIN neurl4

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All Sequences

79
RefSeq

17
UniProt

10
CCDS

CCDS24921.1, CCDS70220.1, CCDS70221.1

Ensembl

ENSMUSG00000047284 (Evidence)
NCBI Gene

216860

			Length	Strain/Species	Flank
genomic	216860	NCBI Gene Model \| MGI Sequence Detail	12104	C57BL/6J	± kb
transcript	NM_001013414	RefSeq \| MGI Sequence Detail	5219	C57BL/6
polypeptide	Q5NCX5	UniProt \| EBI \| MGI Sequence Detail	1563	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011151 neuralized-like protein 4

(term hierarchy)
InterPro Domains

IPR043136 B30.2/SPRY domain superfamily

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR037962 Neuralized

IPR006573 Neuralized homology repeat (NHR) domain
GlyGen

Q5NCX5 1 site, 1 N-linked glycan (1 site)

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All nucleic 127

cDNA 127

Microarray probesets 3

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MGI:2446150

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 18
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Neurl4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102545	Chr11:69791954-69791969 (+)	-583 bp
Tssr102546	Chr11:69792530-69792584 (+)	12 bp
Tssr102547	Chr11:69792674-69792720 (+)	152 bp
Tssr102548	Chr11:69799832-69799843 (+)	7,293 bp
Tssr102549	Chr11:69799846-69799858 (+)	7,307 bp
Tssr102550	Chr11:69802155-69802174 (+)	9,620 bp
Tssr102551	Chr11:69802176-69802186 (+)	9,636 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24