Spmip7 MGI Mouse Gene Detail - MGI:1921112 - sperm microtubule inner protein 7

Symbol

Spmip7
Name

sperm microtubule inner protein 7
Synonyms

4930415F15Rik, post meiotic spermatogenesis 1, Spata48

Feature Type

protein coding gene
IDs

MGI:1921112
NCBI Gene: 73862
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:11412094-11465192 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 6.93 cM, cytoband A2
Mapping Data

2 experiments

SNPs within 2kb

1637 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921112	protein coding gene	Chr11:11412089-11465658 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018044	protein coding gene	Chr11:8738697-8793942 (+)
A/J	MGP_AJ_G0018017	protein coding gene	Chr11:8432429-8489312 (+)
AKR/J	MGP_AKRJ_G0017981	protein coding gene	Chr11:8792658-8847198 (+)
BALB/cJ	MGP_BALBcJ_G0017985	protein coding gene	Chr11:8456180-8508617 (+)
C3H/HeJ	MGP_C3HHeJ_G0017798	protein coding gene	Chr11:8695439-8751656 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018437	protein coding gene	Chr11:9036803-9097620 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016095	protein coding gene	Chr11:8006224-8055698 (+)
CAST/EiJ	MGP_CASTEiJ_G0017360	protein coding gene	Chr11:8714665-8769624 (+)
CBA/J	MGP_CBAJ_G0017773	protein coding gene	Chr11:9678921-9737378 (+)
DBA/2J	MGP_DBA2J_G0017883	protein coding gene	Chr11:8374069-8428021 (+)
FVB/NJ	MGP_FVBNJ_G0017875	protein coding gene	Chr11:8285519-8338035 (+)
LP/J	MGP_LPJ_G0017954	protein coding gene	Chr11:8841591-8901603 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017901	protein coding gene	Chr11:9386987-9464737 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018477	protein coding gene	Chr11:8810686-8868580 (+)
PWK/PhJ	MGP_PWKPhJ_G0017140	protein coding gene	Chr11:8405548-8458552 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016937	protein coding gene	Chr11:8662606-8718881 (+)
WSB/EiJ	MGP_WSBEiJ_G0017414	protein coding gene	Chr11:8571843-8630248 (+)

Human Ortholog

SPMIP7, sperm microtubule inner protein 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPMIP7, sperm microtubule inner protein 7
Synonyms

C7orf72, SPATA48
Links

HGNC:22564

NCBI Gene ID: 100130988

UniProt: A4D263
Chr Location

7p12.2; chr7:50095883-50159256 (+) GRCh38

MGI Vertebrate Homology

Spmip7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPMIP7
Gene Tree

Spmip7

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit azoospermia and decreased testes weight and size.

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All GO Annotations

3
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spmip7

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All Sequences

45
RefSeq

16
UniProt

2
CCDS

CCDS48752.1, CCDS88132.1

Ensembl

ENSMUSG00000020191 (Evidence)
NCBI Gene

73862

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020191	Ensembl Gene Model \| MGI Sequence Detail	53099	C57BL/6J	± kb
transcript	ENSMUST00000020410	Ensembl \| MGI Sequence Detail	1430	Not Applicable
polypeptide	ENSMUSP00000020410	Ensembl \| MGI Sequence Detail	445	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000059683 protein SPMIP7

(term hierarchy)
InterPro Domains

IPR027867 Spermatogenesis-associated protein 48

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All nucleic 1

cDNA 1

Microarray probesets 3

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MGI:5905458, MGI:7470728

Summaries

All 25

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 5
Earliest

J:24282 Pourtier L, et al., Comparison of the sensitivity of C57BL/6J and AKR/J mice to airborne molecules of isovaleric acid and amyl acetate. Behav Genet. 1990 Jul;20(4):499-509
Latest

J:301738 Zhang J, et al., Spermatogenesis-associated 48 is essential for spermatogenesis in mice. Andrologia. 2018 Aug;50(6):e13027

TSS for Spmip7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100344	Chr11:11412079-11412103 (+)	-3 bp
Tssr100345	Chr11:11412490-11412528 (+)	415 bp
Tssr100347	Chr11:11434553-11434568 (+)	22,467 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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