About   Help   FAQ
Lexis1 Gene Detail
Summary
  • Symbol
    Lexis1
  • Name
    lipid responsive LXR-induced inhibitor of cholesterol synthesis 1
  • Synonyms
    4930412L05Rik, LeXis
  • Feature Type
    lncRNA gene
  • IDs
    MGI:1921191
    NCBI Gene: 73941
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:53205057-53217830 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 28.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921191
 lncRNA gene Chr4:53205057-53217857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015547
 unclassified non-coding RNA gene Chr4:51824799-51837281 (-)
A/J MGP_AJ_G0015524
 unclassified non-coding RNA gene Chr4:49835512-49848124 (-)
AKR/J MGP_AKRJ_G0015488
 unclassified non-coding RNA gene Chr4:51199253-51211852 (-)
BALB/cJ MGP_BALBcJ_G0015486
 unclassified non-coding RNA gene Chr4:50016389-50029289 (-)
C3H/HeJ MGP_C3HHeJ_G0015309
 unclassified non-coding RNA gene Chr4:51752044-51764581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0015940
 unclassified non-coding RNA gene Chr4:53740200-53752647 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013675
 unclassified non-coding RNA gene Chr4:46809386-46822427 (-)
CAST/EiJ MGP_CASTEiJ_G0014863
 unclassified non-coding RNA gene Chr4:51392609-51409928 (-)
CBA/J MGP_CBAJ_G0015290
 unclassified non-coding RNA gene Chr4:55556370-55569002 (-)
DBA/2J MGP_DBA2J_G0015384
 unclassified non-coding RNA gene Chr4:49815660-49828300 (-)
FVB/NJ MGP_FVBNJ_G0015391
 unclassified non-coding RNA gene Chr4:49041979-49054555 (-)
LP/J MGP_LPJ_G0015463
 unclassified non-coding RNA gene Chr4:51929725-51942369 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015415
 unclassified non-coding RNA gene Chr4:58812851-58825597 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0015981
 unclassified non-coding RNA gene Chr4:51436275-51450605 (-)
PWK/PhJ MGP_PWKPhJ_G0014649
 unclassified non-coding RNA gene Chr4:49767544-49780939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014437
 unclassified non-coding RNA gene Chr4:50726221-50740123 (-)
WSB/EiJ MGP_WSBEiJ_G0014969
 unclassified non-coding RNA gene Chr4:51326108-51338837 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mcie homozygous for a knock-out allele exhibit increased liver cholesterol and hepatic steatosis in response to a Western diet.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      46
    • RefSeq
      13
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 73941 NCBI Gene Model | MGI Sequence Detail 12774 C57BL/6J ±  kb
    transcript NR_190082 RefSeq | MGI Sequence Detail 1288 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 2
      cDNA 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:6402058
    References
    more
    • Summaries
      All 15
      Phenotypes 2
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:355346 Zhang Z, et al., A PPARgamma/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice. J Clin Invest. 2023 Nov 1;133(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory