Klhl14 MGI Mouse Gene Detail - MGI:1921249

Symbol

Klhl14
Name

kelch-like 14
Synonyms

6330403N15Rik, printor

Feature Type

protein coding gene
IDs

MGI:1921249
NCBI Gene: 225266
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:21683434-21787775 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 11.96 cM
Mapping Data

2 experiments

SNPs within 2kb

2401 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921249	protein coding gene	Chr18:21683434-21805986 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024188	protein coding gene	Chr18:19189136-19297839 (-)
A/J	MGP_AJ_G0024153	protein coding gene	Chr18:18681279-18786793 (-)
AKR/J	MGP_AKRJ_G0024122	protein coding gene	Chr18:19253617-19360944 (-)
BALB/cJ	MGP_BALBcJ_G0024153	protein coding gene	Chr18:18744920-18850348 (-)
C3H/HeJ	MGP_C3HHeJ_G0023921	protein coding gene	Chr18:19188176-19297117 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024595	protein coding gene	Chr18:20087341-20206956 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022037	protein coding gene	Chr18:17778981-17884514 (-)
CAST/EiJ	MGP_CASTEiJ_G0023394	protein coding gene	Chr18:18953436-19073126 (-)
CBA/J	MGP_CBAJ_G0023889	protein coding gene	Chr18:20612914-20739681 (-)
DBA/2J	MGP_DBA2J_G0024021	protein coding gene	Chr18:18375507-18481703 (-)
FVB/NJ	MGP_FVBNJ_G0023987	protein coding gene	Chr18:18155159-18258990 (-)
LP/J	MGP_LPJ_G0024102	protein coding gene	Chr18:19329675-19455428 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024015	protein coding gene	Chr18:21478791-21606000 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024643	protein coding gene	Chr18:19013204-19130955 (-)
PWK/PhJ	MGP_PWKPhJ_G0023139	protein coding gene	Chr18:18426756-18587636 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022948	protein coding gene	Chr18:19195950-19307807 (-)
WSB/EiJ	MGP_WSBEiJ_G0023459	protein coding gene	Chr18:18926486-19040424 (-)

Human Ortholog

KLHL14, kelch like family member 14

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL14, kelch like family member 14
Links

HGNC:29266

NCBI Gene ID: 57565

neXtProt AC: NX_Q9P2G3

UniProt: Q9P2G3
Chr Location

18q12.1; chr18:32672673-32773023 (-) GRCh38

MGI Vertebrate Homology

Klhl14 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL14
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl14

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice heterozygous for the allele exhibit decreased B-1a cells and increased B-1b cells.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

15
cDNA Data

7
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl14

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All Sequences

33
RefSeq

5
UniProt

1
CCDS

CCDS37748.1

Ensembl

ENSMUSG00000042514 (Evidence)
NCBI Gene

225266

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042514	Ensembl Gene Model \| MGI Sequence Detail	104342	C57BL/6J	± kb
transcript	ENSMUST00000122333	Ensembl \| MGI Sequence Detail	4423	Not Applicable
polypeptide	ENSMUSP00000113755	Ensembl \| MGI Sequence Detail	630	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009377 kelch-like protein 14

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR047027 Kelch-like protein 14, BACK domain

IPR030584 Kelch-like protein 14, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 7

cDNA 7

Microarray probesets 2

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MGI:2147262

Summaries

All 36

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:335153 Qiu T, et al., Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464

TSS for Klhl14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152625	Chr18:21785419-21785430 (-)	2,350 bp
Tssr152624	Chr18:21785253-21785264 (-)	2,516 bp
Tssr152623	Chr18:21785148-21785177 (-)	2,612 bp
Tssr152622	Chr18:21785134-21785146 (-)	2,635 bp
Tssr152621	Chr18:21785056-21785072 (-)	2,711 bp
Tssr152620	Chr18:21784870-21784900 (-)	2,890 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24